Artery Research

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Volume 26, Issue 2, June 2020, Pages 97 - 101

Does the Nitric Oxide Synthase T786C Gene Polymorphism Influence Arterial Stiffness in Patients with Metabolic Syndrome?

Authors
Angela Cozma1, †, Adriana Fodor2, †, Lucia Maria Procopciuc3, Teodora Alexescu1, Vasile Negrean1, Dana Pop4, Doina Alina Todea5, Olga Hilda Orăşan1, *, Adela-Viviana Sitar-Taut1
1Internal Medicine Department, “Iuliu Haţieganu” University of Medicine and Pharmacy, Cluj-Napoca, Romania
2Clinical Center of Diabetes, Nutrition, Metabolic diseases, “Iuliu Haţieganu” University of Medicine and Pharmacy, Cluj-Napoca, Romania
3Department of Medical Biochemistry, “Iuliu Haţieganu” University of Medicine and Pharmacy, Cluj-Napoca, Romania
4Department of Cardiology, Clinical Rehabilitation Hospital, “Iuliu Haţieganu” University of Medicine and Pharmacy, Cluj-Napoca, Romania
5Department of Pneumology, “Iuliu Haţieganu” University of Medicine and Pharmacy, Cluj-Napoca, Romania
†

These authors contributed equally to this work.

*Corresponding author. Email: olgaorasan@yahoo.com
Corresponding Author
Olga Hilda Orăşan
Received 15 March 2019, Accepted 24 March 2020, Available Online 4 April 2020.
DOI
10.2991/artres.k.200324.001How to use a DOI?
Keywords
eNOS gene polymorphisms; T786C; arterial stiffness; metabolic syndrome
Abstract

Background: Endothelial Nitric Oxide Synthase (eNOS) is responsible for Nitric Oxide (NO) bioavailability at endothelial level. Aging (even in healthy people) is involved in arterial stiffness increases.

Materials and Methods: We investigated (in the service of Cardiology, 4th Medical Clinic) 100 patients, 55 with metabolic syndrome (MS), mean age 56.91 ± 14.39 years, 66% women. Identification of the T786C polymorphism was performed by enzymatic digestion of the fragment obtained by polymerase chain reaction (PCR) amplification. Evaluation of arterial parameters (aortic pulse wave velocity (PWV), as a measure of arterial stiffness and aortic [AixAo] and brachial [Aixb] augmentation index) was performed with the TensioMed™ Arteriograph.

Results: Regarding T786C polymorphism, the distribution was the following: 57% did not have the mutation (TT), 30% were heterozygous, 13% were homozygous (CC). Patients with MS more frequently had C allele (54.5% vs. 28.9% in those without MS) and CC state (16.4% vs. 8.9%, p-NS). Significant differences (p = 0.005) regarding PWV were found in TT patients vs. heterozygous CT vs. homozygous CC: 9.75 ± 1.75 m/s vs. 9.86 ± 1.56 m/s vs. 11.65 ± 1.87 m/s. In case of the other parameters, no significant differences were found (AixAo, p = 0.35; Aixb, p = 0.22; pulse pressure, p = 0.14), but CC patients presented higher values.

Conclusion: Arterial stiffness is influenced by eNOS gene polymorphisms, being a possible link between the increase in cardiovascular risk and presence of metabolic syndrome in these patients.

Copyright
© 2020 Association for Research into Arterial Structure and Physiology. Publishing services by Atlantis Press International B.V.
Open Access
This is an open access article distributed under the CC BY-NC 4.0 license (http://creativecommons.org/licenses/by-nc/4.0/).

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<Previous Article In Issue
Next Article In Issue>
Journal
Artery Research
Volume-Issue
26 - 2
Pages
97 - 101
Publication Date
2020/04/04
ISSN (Online)
1876-4401
ISSN (Print)
1872-9312
DOI
10.2991/artres.k.200324.001How to use a DOI?
Copyright
© 2020 Association for Research into Arterial Structure and Physiology. Publishing services by Atlantis Press International B.V.
Open Access
This is an open access article distributed under the CC BY-NC 4.0 license (http://creativecommons.org/licenses/by-nc/4.0/).

Cite this article

risenwbib
TY  - JOUR
AU  - Angela Cozma
AU  - Adriana Fodor
AU  - Lucia Maria Procopciuc
AU  - Teodora Alexescu
AU  - Vasile Negrean
AU  - Dana Pop
AU  - Doina Alina Todea
AU  - Olga Hilda Orăşan
AU  - Adela-Viviana Sitar-Taut
PY  - 2020
DA  - 2020/04/04
TI  - Does the Nitric Oxide Synthase T786C Gene Polymorphism Influence Arterial Stiffness in Patients with Metabolic Syndrome?
JO  - Artery Research
SP  - 97
EP  - 101
VL  - 26
IS  - 2
SN  - 1876-4401
UR  - https://doi.org/10.2991/artres.k.200324.001
DO  - 10.2991/artres.k.200324.001
ID  - Cozma2020
ER  -