Formulation, Physical Characteristics and Antioxidant Activity of Chlorophyll-c Emugel Preparation from Brown Seaweed (Sargassum polycystum)

DOI

10.2991/978-2-38476-273-6_48How to use a DOI?

Keywords

Emulgel; Chlorophyll-C; Brown Seaweed; Irritation Test; Physical Characteristics; Antioxidant

Abstract

Brown seaweed (Sargassum polycystum) contains a distinctive pigment, chlorophyll-c. Chlorophyll is known to exhibit strong antibacterial activity against gram-positive bacteria. Emulgel is one of the topical preparations that offers several advantages, including being non-greasy, easy to spread, easy to clean, soft, easy to wash, having a longer shelf life, transparent and comfortable when used. The purpose of this study was to formulate chlorophyll-c isolate in the form of an emulgel preparation to be tested for physical characteristics, antioxidant activity, and irritation tests on rabbits. The research was conducted by isolating chlorophyll-c using column chromatography and preparative thin layer chromatography (PTLC) methods. Emulgel dosage formulations were created with different chlorophyll-c content as the active substance, consisting of FI 0.2%, FII 0.4%, and FIII 0.6%. The results showed that there was an influence of chlorophyll-c concentration on the characteristics of the emulgel preparation. The higher the concentration of chlorophyll-c, the greener the color of the emulgel, the pH decreases, the spreadability decreases, but the viscosity and stickiness increase. Testing of chlorophyll-c emulgel on antioxidant activity showed that the higher the concentration of chlorophyll-c, the greater the antioxidant activity. Giving chlorophyll-c emulgel to rabbits causes very mild irritation with the appearance of erythema or redness and edema that is not very clear.

Copyright

© 2024 The Author(s)

Open Access

Open Access This chapter is licensed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License (http://creativecommons.org/licenses/by-nc/4.0/), which permits any noncommercial use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license and indicate if changes were made.

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TY  - CONF
AU  - Lia Kusmita
AU  - Dinara Safina Firdaus Syifa’
AU  - Mutmainah Mutmainah
PY  - 2024
DA  - 2024/08/02
TI  - Formulation, Physical Characteristics and Antioxidant Activity of Chlorophyll-c Emugel Preparation from Brown Seaweed (Sargassum polycystum)
BT  - Proceedings of 5th Borobudur International Symposium on Humanities and Social Science 2023
PB  - Atlantis Press
SP  - 438
EP  - 446
SN  - 2352-5398
UR  - https://doi.org/10.2991/978-2-38476-273-6_48
DO  - 10.2991/978-2-38476-273-6_48
ID  - Kusmita2024
ER  -