Esterification of Acetic Acid Anhydride with Eugenol and Its Activity as Antifungal

DOI

10.2991/978-2-38476-273-6_70How to use a DOI?

Keywords

Acetyleugenol; Antifungal; Candida albicans; Esterification; Sonochemical

Abstract

The main contents of clove oil are phenolic compounds, namely eugenol, eugenol acetate and gallic acid, as well as flavonoids. One of the derivatives of the eugenol compound is acetyl eugenol which was developed by the esterification reaction between eugenol and acetic acid anhydride using the sonochemical method. The aim of this research is to synthesize the acetyl eugenol compound from the esterification reaction between eugenol and acetic acid anhydride using sonochemical methods, to determine the sonication time that can produce the acetyl eugenol compound with the largest yield percentage, and to determine its antifungal activity against the Candida albicans fungus. Synthesis of acetyleugenol was sonicated for 90 min at a temperature of eighty degrees celsius. The % yield of the synthesized compound is calculated and continued with testing which includes solubility, melting point, FTIR, GC-MS. NMR tests, which are then tested for antifungal activity. The research results show that eugenol and acetic acid anhydride compounds with a NaOH catalyst can be synthesized using ultrasonic waves and produce a % yield of 3.49%. The resulting synthesis can melt starting at a temperature of thirty degrees celcius and can dissolve in ethanol, methanol, chloroform and ether but does not dissolve in distilled water. H-NMR FTIR testing on the acetyl eugenol compound showed the presence of 0,866 (s, 3H)- 6,62 (d,1H)- 6,47 (d, 1H)- 1,875 (t,2H)- 4,983 (s, 2H)- 1,255 (d, 2H)- 7,061 (d,1H)- 3,84 (s, 3H). Acetyleugenol with concentrations of 5% and 10% it shows the ability to act as an antifungal for Candida albicans.

Copyright

© 2024 The Author(s)

Open Access

Open Access This chapter is licensed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License (http://creativecommons.org/licenses/by-nc/4.0/), which permits any noncommercial use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license and indicate if changes were made.

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TY  - CONF
AU  - Rahmawati Salsa Dinurrosifa
AU  - Indah Sulistyarini
AU  - Erwin Indriyanti
PY  - 2024
DA  - 2024/08/02
TI  - Esterification of Acetic Acid Anhydride with Eugenol and Its Activity as Antifungal
BT  - Proceedings of 5th Borobudur International Symposium on Humanities and Social Science 2023
PB  - Atlantis Press
SP  - 645
EP  - 658
SN  - 2352-5398
UR  - https://doi.org/10.2991/978-2-38476-273-6_70
DO  - 10.2991/978-2-38476-273-6_70
ID  - Dinurrosifa2024
ER  -