Chlorogenic Acid Attenuated Inflammatory Response in Kidney Disease with Ischemic Reperfusion Injury
- DOI
- 10.2991/hsic-17.2017.2How to use a DOI?
- Keywords
- acute kidney injury, chlorogenic acid, inflammation, leukocyte
- Abstract
Ischemia reperfusion injury (I/R) at kidney has known as the primary cause of AKI and the most seeing through it. Chlorogenic acid (chlorogenic acid/CGA) is one of the most common polyphenols in the human diet. Chlorogenic acid has an antioxidant effect, antiapoptosis, antiinflammation, antifobrosis. Objective: To investigate the anti-inflammatory effect of chlorogenic acid on the kidneys with I/R injury. Methods: Twenty male mice (3 months-old). The animals were divided into 4 groups, Ischemia reperfusion (IR, n = 5), I/R injury given CGA dose 3.5 mg/kg/BW (IRCGA1, n = 5), I/R injury given CGA dose of 7 mg/kg/BW (IRCGA2, n = 5), and I/R injury given CGA dose 14 mg/kg/BW (IRCGA3, n = 5). The CGA was given intraperitoneally injection for 3 days. At the end of the examination, serum creatinine and leukocytes levels were taken from retroorbital venous blood. The data were analyzed by one-way ANOVA and Kruskal-Wallis statistic test (p <0.05). Results and Conclusion: The IRCGA3 group showed an increase of creatinin serum and leukocytes level compared to the IR group (p <0.05). Chlorogenic acid is known antioxidant and anti-inflammatory can inhibit the inflammatory response
- Copyright
- © 2017, the Authors. Published by Atlantis Press.
- Open Access
- This is an open access article distributed under the CC BY-NC license (http://creativecommons.org/licenses/by-nc/4.0/).
Cite this article
TY - CONF AU - Ali Multazam AU - Sri Rini PY - 2017/10 DA - 2017/10 TI - Chlorogenic Acid Attenuated Inflammatory Response in Kidney Disease with Ischemic Reperfusion Injury BT - Proceedings of the Health Science International Conference (HSIC 2017) PB - Atlantis Press SP - 7 EP - 11 SN - 2468-5739 UR - https://doi.org/10.2991/hsic-17.2017.2 DO - 10.2991/hsic-17.2017.2 ID - Multazam2017/10 ER -