Result of Determination Antioxidant Activity, Toxicity and Liver MDA Level in Gentiana decumbens L.f., Mongolia

Batzaya Gachmaa; Honzhen Yu; Sukhbat Altangerel; Lyankhua Bayasgalankhuu; Khulan Nyamsanjaa; Battseren Tsambaa; Almaz Borjigidai

doi:10.2991/978-94-6463-837-0_15

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Result of Determination Antioxidant Activity, Toxicity and Liver MDA Level in Gentiana decumbens L.f., Mongolia

Authors

Batzaya Gachmaa¹^{, 2}^{, *}, Honzhen Yu³, Sukhbat Altangerel¹, Lyankhua Bayasgalankhuu¹, Khulan Nyamsanjaa¹, Battseren Tsambaa¹^{, *}, Almaz Borjigidai³^{, *}

¹Botanical Garden and Research Institute, Mongolian Academy of Science, Ulaanbaatar, 13330, Mongolia

²University of Mongolian Academy of Science, Ulaanbaatar, 13330, Mongolia

³Key Laboratory of Ethnomedicine of Ministry of Education, Minzu University of China, Beijing, China

^*Corresponding author. Email: batzayag@mas.ac.mn

^*Corresponding author. Email: tseegi.b117@gmail.com

^*Corresponding author. Email: almaz_b@muc.edu.cn

Corresponding Authors

Batzaya Gachmaa, Battseren Tsambaa, Almaz Borjigidai

Available Online 17 September 2025.

DOI: 10.2991/978-94-6463-837-0_15 How to use a DOI?
Keywords: IC50; Liver deseases; Toxicity (LD50; LC50); MDA
Abstract: Gentiana decumbens L.f. had a common status in Mongolia and frequently used in liver diseases in Mongolian medicine recipes. Our goal is to conduct a basic study to develop biologically active products for liver disorders. We determined the antioxidant activity, toxicity, and acute toxicity of the Gentiana decumbens L.f. extract, and evaluated its inhibitory activity on MDA (malondialdehyde), a peroxidation intermediate formed in the liver by DMF (dimethylformamide). Toxicity (LC₅₀) was determined using brine shrimp (Artemia nauplii) using the Clarkson index, acute toxicity in Balb/C mice was assessed using the Sidirov K.K. (LD₅₀) classification, and MDA levels were assessed in mice livers using the Stalnaya method. The strong antioxidant activity of 29.95±0.29 μg/ml, non-toxic (1340- 2628.38 μg/ml) by Clarkson’s index, low toxic (0.55±0.24 g/kg) according to Sidirov K.K.’s classification in acute toxicity that results from Gentiana decumbens extract. Furthermore, when evaluated at different times (24, 48, and 72 hours), Gentiana decumbens extract shown 1.25-2.57 times stronger inhibitory action against liver MDA (an enzyme produced during liver inflammation) in mice when compared to the control group. According to these findings Gentiana decumbens has anti-inflammatory and anti-liver disease properties. Furthermore, it may be a source of biologically active products for liver disorders.
Open Access: Open Access This chapter is licensed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License (http://creativecommons.org/licenses/by-nc/4.0/), which permits any noncommercial use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license and indicate if changes were made.

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Volume Title: Proceedings of the International Biological Conference in Mongolia 2025 (IBCM 2025)
Series: Advances in Biological Sciences Research
Publication Date: 17 September 2025
ISBN: 978-94-6463-837-0
ISSN: 2468-5747
DOI: 10.2991/978-94-6463-837-0_15 How to use a DOI?
Open Access: Open Access This chapter is licensed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License (http://creativecommons.org/licenses/by-nc/4.0/), which permits any noncommercial use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license and indicate if changes were made.

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ris enw bib

TY  - CONF
AU  - Batzaya Gachmaa
AU  - Honzhen Yu
AU  - Sukhbat Altangerel
AU  - Lyankhua Bayasgalankhuu
AU  - Khulan Nyamsanjaa
AU  - Battseren Tsambaa
AU  - Almaz Borjigidai
PY  - 2025
DA  - 2025/09/17
TI  - Result of Determination Antioxidant Activity, Toxicity and Liver MDA Level in Gentiana decumbens L.f., Mongolia
BT  - Proceedings of the International Biological Conference in Mongolia 2025 (IBCM 2025)
PB  - Atlantis Press
SP  - 211
EP  - 223
SN  - 2468-5747
UR  - https://doi.org/10.2991/978-94-6463-837-0_15
DO  - 10.2991/978-94-6463-837-0_15
ID  - Gachmaa2025
ER  -

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