Maternal Isodisomy of Chromosome 13: A Case Study Linking Genetic Inheritance, Nutrition-Related Traits, and Sustainable Health Outcomes

DOI

10.2991/978-2-38476-583-6_14How to use a DOI?

Keywords

Maternal uniparental disomy; Chromosome 13; Paternity testing; Forensic case; Nutritional genomics; Population health genetics; STRs (Short Tandem Repeats)

Abstract

A rare genetic disorder known as Uniparental disomy (UPD) occurs when both chromosomal copies are received by the child from one parent and not following the Mendelian inheritance laws. Although, UPD primarily investigated within the domains of medical genetics and forensic science, but it also carries important implications for food, nutrition, and healthcare practices. The present observation of maternal UPD of chromosome 13 in a child, identified during routine forensic parentage analysis using autosomal STR and Y-STR profiling, highlights the broader relevance of such rare genetic events beyond inheritance anomalies. Since, chromosome 13 harbors genes related to growth regulation, metabolic pathways, immune function, and disease susceptibility. Therefore, nutritional needs, growth patterns and long-term health consequences are indirectly impacted by aberrant inheritance patterns like UPD which can influence gene dosage, imprinting effects, and recessive disease expression. From a healthcare perspective, nutritional planning and dietary interventions may need to be tailored in individuals with chromosomal abnormalities to support optimal growth and metabolic balance. In public health contexts, awareness of rare genetic mechanisms such as maternal isodisomy of chromosome 13 underscores the need for interdisciplinary approaches linking genetics, nutrition, and preventive medicine. Despite its potential significance, research connecting UPD with nutritional status and healthcare strategies remains limited. Addressing this gap could enhance understanding of genotype–phenotype relationships and support evidence-based practices in food sustainability, nutritional counseling, and healthcare planning. Thus, forensic genetic findings not only resolve legal questions but also offer valuable insights relevant to holistic health and nutrition frameworks.

Copyright

© 2026 The Author(s)

Open Access

Open Access This chapter is licensed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License (http://creativecommons.org/licenses/by-nc/4.0/), which permits any noncommercial use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license and indicate if changes were made.

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TY  - CONF
AU  - Bhawna Poonia
AU  - Sangita Gupta
PY  - 2026
DA  - 2026/06/30
TI  - Maternal Isodisomy of Chromosome 13: A Case Study Linking Genetic Inheritance, Nutrition-Related Traits, and Sustainable Health Outcomes
BT  - Proceedings of the International Conference on Emerging Food Studies: Intersections of Culture, Science and Sustainability (ICEFS 2026)
PB  - Atlantis Press
SP  - 149
EP  - 160
SN  - 2352-5398
UR  - https://doi.org/10.2991/978-2-38476-583-6_14
DO  - 10.2991/978-2-38476-583-6_14
ID  - Poonia2026
ER  -