Molecular Autopsy: Integrating Discovery and Precision thorough Next Generation Sequencing with Emerging Prospects for the Future

DOI

10.2991/978-94-6239-610-4_47How to use a DOI?

Keywords

Sanger sequencing; Next generation sequencing; Forensic genetics; Molecular autopsy; sudden unexplained death; disorders of genes

Abstract

Molecular autopsy has evolved as a crucial technique in forensics and identification of medical condition specifically in revealing the genetic architecture of sudden death where conventional autopsy results remain in definitive. With evolution in Genomic sequencing two significant methods NGS (next generation sequencing) as well as Sanger sequencing have majorly contributed to the field. It retains its utility for the confirmation of genetic differences, verifying results from Automated large scale processing systems and researching specific gene alteration accompanied by genetic disorders. Nevertheless, its confined as well as high cost per base makes it ineffective for extensive investigation. It validates comprehensive examination of whole genomes, assisting the detection of disease-causing genes connected to Cardiac channelopathies, Metabolism errors and various Congenital diseases often intertwined in SUD’s (sudden unexplained death). Furthermore, standardizing databases and procedures is crucial to enhancing reliability and reproducibility across many labs. The incorporation of bioinformatics technologies and international collaboration are also key factors in improving the precision of variant interpretation. In the end, molecular autopsy will continue to develop as a revolutionary method in both forensic and clinical medicine thanks to the cooperation of sophisticated sequencing technology, through data analysis, and ethical consideration.

Copyright

© 2026 The Author(s)

Open Access

Open Access This chapter is licensed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License (http://creativecommons.org/licenses/by-nc/4.0/), which permits any noncommercial use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license and indicate if changes were made.

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TY  - CONF
AU  - Tanu Rajput
AU  - Aditya Verma
AU  - Devesh Tiwari
PY  - 2026
DA  - 2026/05/05
TI  - Molecular Autopsy: Integrating Discovery and Precision thorough Next Generation Sequencing with Emerging Prospects for the Future
BT  - Proceedings of the First International Conference on Advances in Forensics and Cyber Technologies (ICFACT 2025)
PB  - Atlantis Press
SP  - 533
EP  - 548
SN  - 2352-538X
UR  - https://doi.org/10.2991/978-94-6239-610-4_47
DO  - 10.2991/978-94-6239-610-4_47
ID  - Rajput2026
ER  -