Effectiveness of Kersen Leaf (Muntingia Calabura L.) Extract on Rats as an anti-Diabetic Agent

DOI

10.2991/978-94-6463-664-2_26How to use a DOI?

Keywords

Diabetes Mellitus; Kersen Leaf; Ethanol; Alloxan and Wistar Rats

Abstract

Diabetes Mellitus (DM) is a chronic metabolic disease with many causes and is characterized by elevated blood sugar levels caused by failure of insulin secretion or insulin action. Many plant secondary metabolite compounds can be used as medicine. Kersen Leaves (Muntingia Calabura L.) have secondary metabolites that function as antioxidants and can produce the hormone insulin, which helps metabolize sugar. Therefore, this study investigated the effectiveness of Kersen Leaf in lowering blood glucose. This study uses a type of pure Experimental Research (True Experimental) and the design uses Pretest-Posttest Control Group Design. Then, the rats were grouped into 5 different groups, namely Group I (Negative Control), Group II (Positive Control), Group III (Kersen Leaf Extract 150 mg/kgBW/day), Group IV (Kersen Leaf Extract 300 mg/kgBW/day), Group V (Kersen Leaf Extract 600 mg/kgBW/day). Meanwhile, Kersen Leaves used in this study were extracted by maceration method using ethanol solvent. The results of this study showed that Kersen Leaf Ethanol Extract can significantly reduce blood sugar levels after 10 days to 15 days after administration of Kersen Leaf Ethanol Extract (P Value < 0, 05). Thus, it can be concluded that Kersen Leaf Ethanol Extract can reduce blood sugar levels after 5 days of treatment.

Copyright

© 2025 The Author(s)

Open Access

Open Access This chapter is licensed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License (http://creativecommons.org/licenses/by-nc/4.0/), which permits any noncommercial use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license and indicate if changes were made.

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TY  - CONF
AU  - Astriani Natalia
AU  - Hilda Karolina
AU  - Rena Meutia
AU  - Asyrun Alkhairi Lubis
PY  - 2025
DA  - 2025/03/31
TI  - Effectiveness of Kersen Leaf (Muntingia Calabura L.) Extract on Rats as an anti-Diabetic Agent
BT  - Proceedings of the 1st International Conference on Lifestyle Diseases and Natural Medicine (ICOLIFEMED 2024)
PB  - Atlantis Press
SP  - 283
EP  - 294
SN  - 2468-5739
UR  - https://doi.org/10.2991/978-94-6463-664-2_26
DO  - 10.2991/978-94-6463-664-2_26
ID  - Natalia2025
ER  -