Therapeutic Implications of Targeted Cancer for Autophagy Modulation by RNA-Binding Proteins and Mitochondrial Genes in Tumor Pathogenesis

DOI

10.2991/978-94-6463-910-0_19How to use a DOI?

Keywords

Autophagy; cancer; RNA-binding proteins; mitochondrial genes; targeted therapy

Abstract

Autophagy is a highly conserved lysosomal degradation pathway that plays a crucial and multifaceted role in maintaining cellular homeostasis. It is a process by which cells sequester damaged organelles, misfolded proteins, and other cytoplasmic components within double-membraned autophagosomes. This review explores how neurodegenerative disease-associated genes (hnRNPA1, hnRNPA2B1, CHCHD10, DAO, Pfn1), originally linked to autophagy dysregulation in neurons, critically influence autophagy in cancers. We present evidence showing that these genes modulate autophagic flux via LC3-II/LC3-I ratio and p62/SQSTM1 dynamics in a tissue-specific manner. In glioblastoma, hnRNPA1 knockdown inhibits autophagosome maturation, exacerbating chemoresistance; in breast cancer, CHCHD10 mutations disrupt mitochondrial turnover, driving metastasis. Conversely, DAO knockout elevates autophagy, suppressing hepatocellular carcinoma growth. We further discuss therapeutic strategies targeting these pathways, including CRISPR-based gene editing and small-molecule inhibitors. This mechanistic convergence between neurodegeneration and oncology highlights novel targets for precision cancer therapy.

Copyright

© 2025 The Author(s)

Open Access

Open Access This chapter is licensed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License (http://creativecommons.org/licenses/by-nc/4.0/), which permits any noncommercial use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license and indicate if changes were made.

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TY  - CONF
AU  - Qintao Li
PY  - 2025
DA  - 2025/12/15
TI  - Therapeutic Implications of Targeted Cancer for Autophagy Modulation by RNA-Binding Proteins and Mitochondrial Genes in Tumor Pathogenesis
BT  - Proceedings of the 2025 2nd International Symposium on Agricultural Engineering and Biology (ISAEB 2025)
PB  - Atlantis Press
SP  - 176
EP  - 182
SN  - 2468-5747
UR  - https://doi.org/10.2991/978-94-6463-910-0_19
DO  - 10.2991/978-94-6463-910-0_19
ID  - Li2025
ER  -