Proceedings of the International symposium on Sustainable Drug Design and Nanoparticle development: Quantum and Computational Perspectives (SDDNDQCP 2025)

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Unraveling the Synergistic Anti-Diabetic and Anti-Hyperlipedimic Effects of Madhumeha Nivarana Churnam

Authors
B. N. B. Vaidehi1, *, K. Ravi Shankar2, K. Gnaneswari2
1Department of Pharmaceutical Chemistry, Aditya College of Pharmacy, University, Surampalem, Kakinada, Andhra Pradesh, India
2Department of Pharmacology, Aditya College of Pharmacy, University, Surampalem, Kakinada, Andhra Pradesh, India
*Corresponding author. Email: bnb.vaidehi@acop.edu.in
Corresponding Author
B. N. B. Vaidehi
Available Online 13 August 2025.
DOI
10.2991/978-94-6463-813-4_6How to use a DOI?
Keywords
Madhumeha Nivarana Churnam; Lipid profiles; Hypoglycemic; Insulin
Abstract

Traditionally applied medicinal plants are of great importance, and the trend of using these medicinal plants is increasingly important in the world due to their fewer side effects. Madhumeha Nivarana Churnam is an indigenous ayurvedic formulation is focused on this research study to establish the claimed hypoglycemic and hypolipidemic activities manufactured by Anjaneya herbals. This formulation is prepared with several medicinal herbs consisting of Andrographis serpyllifolia, Tinospora cordifolia, Trigonella foenun graecum, Withania somnifera, Triphala [Emblica officinalis, Terminalia bellirica and Terminalia chebula], Aloe barbadensis miller for the treatment of hyperglycemia and hypolipidemia. No documented scientific research is reported; hence a sincere attempt is initiated to take up a research study on this formulation to demonstrate the justification of possible biological effect of this formulation. Alloxan induced diabetic rats of either sex was selected for the study to evaluate the hypoglycemic, and hypolipidemic activities and serum insulin levels were also estimated by using the standard RIA method. The histopathological studies of diabetic rat pancreas were determined. Further Molecular docking investigations of important Madhumeha Nivarana Churnam components by using Autodock software could also support the findings against a novel antidiabetic target, PTP1B (protein tyrosine Phosphatase-1B).

Copyright
© 2025 The Author(s)
Open Access
Open Access This chapter is licensed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License (http://creativecommons.org/licenses/by-nc/4.0/), which permits any noncommercial use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license and indicate if changes were made.

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Volume Title
Proceedings of the International symposium on Sustainable Drug Design and Nanoparticle development: Quantum and Computational Perspectives (SDDNDQCP 2025)
Series
Advances in Health Sciences Research
Publication Date
13 August 2025
ISBN
978-94-6463-813-4
ISSN
2468-5739
DOI
10.2991/978-94-6463-813-4_6How to use a DOI?
Copyright
© 2025 The Author(s)
Open Access
Open Access This chapter is licensed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License (http://creativecommons.org/licenses/by-nc/4.0/), which permits any noncommercial use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license and indicate if changes were made.

Cite this article

risenwbib
TY  - CONF
AU  - B. N. B. Vaidehi
AU  - K. Ravi Shankar
AU  - K. Gnaneswari
PY  - 2025
DA  - 2025/08/13
TI  - Unraveling the Synergistic Anti-Diabetic and Anti-Hyperlipedimic Effects of Madhumeha Nivarana Churnam
BT  - Proceedings of the International symposium on Sustainable Drug Design and Nanoparticle development: Quantum and Computational Perspectives (SDDNDQCP 2025)
PB  - Atlantis Press
SP  - 57
EP  - 74
SN  - 2468-5739
UR  - https://doi.org/10.2991/978-94-6463-813-4_6
DO  - 10.2991/978-94-6463-813-4_6
ID  - Vaidehi2025
ER  -