Design, Development, and Characterization of Atorvastatin Calcium Nanocrystal for Improved Oral Bioavailability

DOI

10.2991/978-94-6463-813-4_8How to use a DOI?

Keywords

Atorvastatin Calcium; Nanocrystals; Solvent Antisolvent Precipitation Method; and Bioavailability

Abstract

The objective of the study was to elevate the solubility, dissolution, and oral bioavailability of a practically insoluble hyperlipidemia drug Atorvastatin calcium. 2³ factorial design and solvent antisolvent precipitation were used to create atorvastatin calcium nanocrystals (NCs). Particle size, drug content, surface morphology, saturation solubility, zeta potential, and in vitro release studies were all assessed in a variety of trials. Three parameters i.e., stabilizer (Pluronic F-127) concentration, solvent antisolvent ratio, and stirring time were examined for their effects on NCs characteristics. FTIR studies indicate no drug-polymer interactions. NCs had a zeta potential value of -38.2 mv with particle sizes varying from 128 to 316 nm. SEM was utilized to investigate the surface morphology of NCs, which showed a typical spherical structure with a uniform surface free of collapse. The drug content of NCs varied from 50 to 78. When compared to the pure drug, the optimized formulation NCs demonstrated a significant improvement in saturation solubility and a quick rate of dissolution. The production of Atorvastatin calcium NCs using solvent antisolvent precipitation technique could enhance the drug’s solubility, dissolution, and bioavailability, which may solve the issues related to traditional formulations such as tablets.

Copyright

© 2025 The Author(s)

Open Access

Open Access This chapter is licensed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License (http://creativecommons.org/licenses/by-nc/4.0/), which permits any noncommercial use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license and indicate if changes were made.

Download article (PDF)

TY  - CONF
AU  - Sadhu Venkateswara Rao
AU  - S. Deepthi
AU  - T. Pavani
AU  - B. Mounika
PY  - 2025
DA  - 2025/08/13
TI  - Design, Development, and Characterization of Atorvastatin Calcium Nanocrystal for Improved Oral Bioavailability
BT  - Proceedings of the International symposium on Sustainable Drug Design and Nanoparticle development: Quantum and Computational Perspectives (SDDNDQCP 2025)
PB  - Atlantis Press
SP  - 92
EP  - 108
SN  - 2468-5739
UR  - https://doi.org/10.2991/978-94-6463-813-4_8
DO  - 10.2991/978-94-6463-813-4_8
ID  - Rao2025
ER  -