Advances and Perspectives Chitosan-Sodium Tripolyphosphate as an Effective Drug Delivery System for Skin Applications

DOI

10.2991/978-94-6239-762-0_14How to use a DOI?

Keywords

Chitosan; Sodium Tripolyphosphate; Nanoparticles; Topical Drug Delivery

Abstract

Effective topical drug delivery systems pose a significant challenge in dermatological therapy, particularly in overcoming physiological barriers such as stratum corneum penetration, ensuring drug stability, and preventing uncontrolled release. Chitosan–sodium tripolyphosphate (TPP)-based nanoparticles offer an innovative solution, providing advantages in bioadhesion, biocompatibility, encapsulation efficiency, and controlled drug release capabilities. This article reviews recent advances in the formulation, physicochemical characteristics, and mechanism of action of chitosan–TPP nanoparticles in enhancing permeability and therapeutic efficacy. Additionally, this article reviews the potential of this system in delivering various types of active compounds, including those from natural extracts and synthetic drugs. It compares it with other polymer-based nano-particle systems. Advanced formulation approaches, such as ultrasonication after ionic gelation, are also discussed as a strategy to improve particle size and stability of the preparations. Applications include wound healing, skin cancer therapy, treatment of chronic inflammation, and delivery of cosmetic active ingredients. With a multidisciplinary approach and adequate clinical validation, chitosan–TPP nanoparticles have the potential to become a new standard in adaptive, efficient, and personalized dermal drug delivery systems.

Copyright

© 2026 The Author(s)

Open Access

Open Access This chapter is licensed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License (http://creativecommons.org/licenses/by-nc-nd/4.0/), which permits any noncommercial use, sharing, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license and indicate if you modified the licensed material. You do not have permission under this license to share adapted material derived from this chapter or parts of it.

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TY  - CONF
AU  - Gusti Ayu Nyoman Tri Isa Partama
AU  - Nanang Fakhrudin
AU  - Adhyatmika Adhyatmika
PY  - 2026
DA  - 2026/09/04
TI  - Advances and Perspectives Chitosan-Sodium Tripolyphosphate as an Effective Drug Delivery System for Skin Applications
BT  - Proceedings of the 6th International Conference on Bioinformatics, Biotechnology, and Biomedical Engineering (BIOMIC 2025)
PB  - Atlantis Press
SP  - 205
EP  - 237
SN  - 2468-5739
UR  - https://doi.org/10.2991/978-94-6239-762-0_14
DO  - 10.2991/978-94-6239-762-0_14
ID  - Partama2026
ER  -