Preparation and Optimization of Curcumin Liposomes by the Thin-Film Dispersion Method to Enhance Antibacterial Efficacy

DOI

10.2991/978-94-6463-829-5_19How to use a DOI?

Keywords

Curcumin; Liposome; Preparation process; Film dispersion method; Hydrogenated lecithin; Antibacterial activity

Abstract

To enhance the water solubility and stability of curcumin and to enhance its antibacterial efficacy, this study prepared curcumin liposomes using hydrogenated lecithin as the primary material and Tween 80 for surface modification. The preparation process employed thin film dispersion and high-pressure homogenization techniques. The effects of membrane ratio, drug-to-lipid ratio, hydration time, and hydration temperature on the preparation of curcumin liposomes were investigated through single-factor experiments. Orthogonal experimental design was employed to optimize the preparation process of curcumin liposomes. Additionally, the encapsulation efficiency, particle size, morphology, stability, and antibacterial activity of the liposomes were evaluated. The research results show that under the conditions of a membrane material ratio of 3:1, a drug-lipid ratio of 1:10, a hydration temperature of 40 ℃, and a hydration time of 75 minutes, the encapsulation efficiency of the prepared liposomes reached 70.95 ± 3.51%, the particle size was 360.02 ± 2.43 nm, and the polydispersity index was 0.2736 ± 0.009. This liposome can remain stable for up to 28 days and exhibits the best antibacterial effect. Additionally, the liposomes modified with Tween 80 are significantly superior to unmodified liposomes in terms of water solubility, stability, and the ability to inhibit E. coli. This research provides theoretical support for the application of curcumin in food products and pharmaceuticals.

Copyright

© 2025 The Author(s)

Open Access

Open Access This chapter is licensed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License (http://creativecommons.org/licenses/by-nc/4.0/), which permits any noncommercial use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license and indicate if changes were made.

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TY  - CONF
AU  - Siqi Wei
AU  - Qingqing Huang
AU  - Shuhua Zhong
AU  - Liye Wen
AU  - Chunyu Li
AU  - Minyi Huang
AU  - Tao Jiang
PY  - 2025
DA  - 2025/08/28
TI  - Preparation and Optimization of Curcumin Liposomes by the Thin-Film Dispersion Method to Enhance Antibacterial Efficacy
BT  - Proceedings of the 2025 International Conference on Chemical Engineering and Biological Science (CEBS 2025)
PB  - Atlantis Press
SP  - 168
EP  - 179
SN  - 2352-5401
UR  - https://doi.org/10.2991/978-94-6463-829-5_19
DO  - 10.2991/978-94-6463-829-5_19
ID  - Wei2025
ER  -