Biomaterials for the Construction of Functional Liver Organoids

Tegshjargal Badamjav; Riao Dao; Yundendash Dashzeveg; Bayar Hexig

doi:10.2991/978-94-6463-837-0_18

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Biomaterials for the Construction of Functional Liver Organoids

Authors

Tegshjargal Badamjav¹^{, 2}, Riao Dao³, Yundendash Dashzeveg⁴, Bayar Hexig¹^{, 2}^{, *}

¹State Key Laboratory of Reproductive Regulation and Breeding of Grassland Livestock, School of Life Science, Inner Mongolia University, Hohhot, Inner Mongolia Autonomous Region, 010020, China

²Department of Internal Medicine, Institute of Medical Sciences, Ulaanbaatar, 15160, Mongolia

³State Key Laboratory of Reproductive Regulation and Breeding of Grassland Livestock, School of Life Science, Inner Mongolia University, Hohhot, Inner Mongolia Autonomous Region, 010020, China

⁴Central Research Laboratory, Institute of Medical Sciences, Ulaanbaatar, 15160, Mongolia

^*Corresponding author. Email: bhexig@imu.edu.cn

Corresponding Author

Bayar Hexig

Available Online 17 September 2025.

DOI: 10.2991/978-94-6463-837-0_18 How to use a DOI?
Keywords: Biomaterial; Functional; Liver organoid; Construction
Abstract: The construction of liver organoids that precisely recapitulate the intricate architecture and physiological functions of native liver tissue represents a pivotal research direction in biomedical engineering, offering a transformative technological platform for innovative drug development, precision medicine strategies, and regenerative therapies for end-stage liver diseases. Given its central role in maintaining systemic metabolic homeostasis, hepatic dysfunction can lead to severe pathological conditions including cirrhosis, hepatitis, and hepatocellular carcinoma, underscoring the urgent need to develop effective therapeutic interventions and innovative approaches for liver diseases. Conventional two-dimensional (2D) culture models often fail to recapitulate the intricate three-dimensional architecture and diverse cell-cell interactions characteristic of native liver tissue, thereby limiting their accuracy in disease modeling and drug evaluation. Three-dimensional (3D) hepatocyte cultures have gained increasing application in liver physiology research, as they provide a more physiologically relevant system that better mimics the hepatic microenvironment compared to traditional 2D monolayer cultures, while organoids can effectively capture the complexity of liver tissue. In contrast to these conventional methods, liver organoids offer a robust platform for replicating the structural and functional complexity of the liver, with significant potential to overcome the limitations of traditional cell culture models, thereby advancing liver-related research and clinical applications. Future advancements should prioritize advanced engineering strategies, such as the use of defined media, precise protein delivery systems, tailored ECM materials, and integration of microfluidic technology to ensure accurate reproduction of liver histopathology and physiological characteristics.
Open Access: Open Access This chapter is licensed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License (http://creativecommons.org/licenses/by-nc/4.0/), which permits any noncommercial use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license and indicate if changes were made.

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Volume Title: Proceedings of the International Biological Conference in Mongolia 2025 (IBCM 2025)
Series: Advances in Biological Sciences Research
Publication Date: 17 September 2025
ISBN: 978-94-6463-837-0
ISSN: 2468-5747
DOI: 10.2991/978-94-6463-837-0_18 How to use a DOI?
Open Access: Open Access This chapter is licensed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License (http://creativecommons.org/licenses/by-nc/4.0/), which permits any noncommercial use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license and indicate if changes were made.

Cite this article

ris enw bib

TY  - CONF
AU  - Tegshjargal Badamjav
AU  - Riao Dao
AU  - Yundendash Dashzeveg
AU  - Bayar Hexig
PY  - 2025
DA  - 2025/09/17
TI  - Biomaterials for the Construction of Functional Liver Organoids
BT  - Proceedings of the International Biological Conference in Mongolia 2025 (IBCM 2025)
PB  - Atlantis Press
SP  - 250
EP  - 273
SN  - 2468-5747
UR  - https://doi.org/10.2991/978-94-6463-837-0_18
DO  - 10.2991/978-94-6463-837-0_18
ID  - Badamjav2025
ER  -

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