Proceedings of the 5th International Conference on Applied Sciences, Mathematics, and Informatics (ICASMI 2024)

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Correlation Analysis of HbA2 Levels with Erythrocyte Index in Beta-Thalassemia Patients at RSUD Dr. H. Abdul Moeloek Lampung Province in 2023

Authors
Putu Ristyaning Ayu Sangging1, *, Fathan Qoriba1, Hendri Busman2, Khairunisa Berawi1, Maulana1
1Faculty of Medical, Lampung University, Bandar Lampung, Indonesia
2Faculty of Mathematics and Natural Sciences, Lampung University, Bandar Lampung, Indonesia
*Corresponding author. Email: ristya.ayu@gmail.com
Corresponding Author
Putu Ristyaning Ayu Sangging
Available Online 27 May 2025.
DOI
10.2991/978-94-6463-730-4_20How to use a DOI?
Keywords
HbA2; Erythrocyte Index; Beta-thalassemia
Abstract

Thalassemia is a genetic disorder that cause impaired hemoglobin production. Hemoglobin gets destroyed dua to impaired synthesis of hemoglobin chains or globin chains. The purpose of this study was to explore the correlation between hemoglobin A2 (HbA2) levels and erythrocyte index in thalassemia patients at Dr. H. Abdul Moeloek Hospital, Lampung Province in 2023. This study used an analytical observational method with a cross-sectional approach with total sampling technique. The number of samples was 39 beta thalassemia patients who fit the inclusion and exclusion criteria. The research was conducted in September-November 2024 at the Medical Record Installation of Dr. H. Abdul Moeloek Hospital Lampung Province. Data were analyzed univariate and bivariate with Spearman correlation test to determine the relationship between HbA2 and each erythrocyte index. It was found that most subjects had increased hbA2 levels (66.7%) and decreased MCV (97.4%) and MCH (92.3%) levels. There was a significant correlation between HbA2 levels with MCV (p= 0.001; r= -0.525) and HbA2 with MCV (p=0.001; r= -0.508). This study shows that increased HbA2 levels correlated with decreased MCV and MCH values in beta-thalassemia patients, while there is no significant correlation with MCHC.

Copyright
© 2025 The Author(s)
Open Access
Open Access This chapter is licensed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License (http://creativecommons.org/licenses/by-nc/4.0/), which permits any noncommercial use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license and indicate if changes were made.

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Volume Title
Proceedings of the 5th International Conference on Applied Sciences, Mathematics, and Informatics (ICASMI 2024)
Series
Advances in Physics Research
Publication Date
27 May 2025
ISBN
978-94-6463-730-4
ISSN
2352-541X
DOI
10.2991/978-94-6463-730-4_20How to use a DOI?
Copyright
© 2025 The Author(s)
Open Access
Open Access This chapter is licensed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License (http://creativecommons.org/licenses/by-nc/4.0/), which permits any noncommercial use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license and indicate if changes were made.

Cite this article

risenwbib
TY  - CONF
AU  - Putu Ristyaning Ayu Sangging
AU  - Fathan Qoriba
AU  - Hendri Busman
AU  - Khairunisa Berawi
AU  - Maulana
PY  - 2025
DA  - 2025/05/27
TI  - Correlation Analysis of HbA2 Levels with Erythrocyte Index in Beta-Thalassemia Patients at RSUD Dr. H. Abdul Moeloek Lampung Province in 2023
BT  - Proceedings of the 5th International Conference on Applied Sciences, Mathematics, and Informatics (ICASMI 2024)
PB  - Atlantis Press
SP  - 233
EP  - 244
SN  - 2352-541X
UR  - https://doi.org/10.2991/978-94-6463-730-4_20
DO  - 10.2991/978-94-6463-730-4_20
ID  - Sangging2025
ER  -