Proceedings of the 1st International Conference on Lifestyle Diseases and Natural Medicine (ICOLIFEMED 2024)

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Pancreatic Protective Effects of Combination Nanoparticle Granule Sunkist Orange and Lime Peel in Diabetic Rats

Authors
Maya Sari Mutia1, *, Desi Danilah Irwanda2, Putri Nabila2, Ulpah Zahara Hamsi2, Widya Yanti Sihotang3
1Department of Medicine, Faculty of Medicine, Dentistry and Health Science, Universitas Prima Indonesia, Medan, Indonesia
2Department of Medicine, Faculty of Medicine, Dentistry and Health Science, Universitas Prima Indonesia, Medan, Indonesia
3Department of Public Health, Faculty of Medicine, Dentistry and Health Science, Universitas Prima Indonesia, Medan, Indonesia
*Corresponding author. Email: mayasarimutia@unprimdn.ac.id
Corresponding Author
Maya Sari Mutia
Available Online 31 March 2025.
DOI
10.2991/978-94-6463-664-2_23How to use a DOI?
Keywords
Antioxidant; Diabetes Mellitus; GNSLP; Pancreas; Oxidative stress
Abstract

Sunkist orange and lime peels contain flavonoids with strong antioxidant properties, capable of preventing lipid oxidation and neutralizing free radicals. These antioxidants are promising for addressing pancreatic cell damage in diabetes, which is often caused by oxidative stress. This study evaluated the potential of nanoparticle granules containing sunkist orange and lime peel extracts (GNSLP) to repair pancreatic damage in diabetic rats. A Post-Test Only Control Group Design was employed, involving 25 male Wistar rats divided into five groups: negative control (alloxan), positive control (aquadest), and three treatment groups administered alloxan and GNSLP granules at doses of 50, 100, and 200 mg/kgBW. Parameters assessed included MDA levels, pancreatic enzymes (amylase and lipase), and histopathological analysis. Results showed significant improvements in pancreatic function, reduced MDA levels, and enhanced histopathology across all doses, with optimal effects at 200 mg/kgBW (p<0.001). GNSLP nanoparticle granules demonstrate great potential for pancreatic repair in diabetic conditions.

Copyright
© 2025 The Author(s)
Open Access
Open Access This chapter is licensed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License (http://creativecommons.org/licenses/by-nc/4.0/), which permits any noncommercial use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license and indicate if changes were made.

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Volume Title
Proceedings of the 1st International Conference on Lifestyle Diseases and Natural Medicine (ICOLIFEMED 2024)
Series
Advances in Health Sciences Research
Publication Date
31 March 2025
ISBN
978-94-6463-664-2
ISSN
2468-5739
DOI
10.2991/978-94-6463-664-2_23How to use a DOI?
Copyright
© 2025 The Author(s)
Open Access
Open Access This chapter is licensed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License (http://creativecommons.org/licenses/by-nc/4.0/), which permits any noncommercial use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license and indicate if changes were made.

Cite this article

risenwbib
TY  - CONF
AU  - Maya Sari Mutia
AU  - Desi Danilah Irwanda
AU  - Putri Nabila
AU  - Ulpah Zahara Hamsi
AU  - Widya Yanti Sihotang
PY  - 2025
DA  - 2025/03/31
TI  - Pancreatic Protective Effects of Combination Nanoparticle Granule Sunkist Orange and Lime Peel in Diabetic Rats
BT  - Proceedings of the 1st International Conference on Lifestyle Diseases and Natural Medicine (ICOLIFEMED 2024)
PB  - Atlantis Press
SP  - 245
EP  - 255
SN  - 2468-5739
UR  - https://doi.org/10.2991/978-94-6463-664-2_23
DO  - 10.2991/978-94-6463-664-2_23
ID  - Mutia2025
ER  -