Proceedings of the 1st International Conference on Lifestyle Diseases and Natural Medicine (ICOLIFEMED 2024)

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The Role of Bioactive Compounds from Paraboea leuserensis on VEGF expression of Wound Healing

Authors
Refi Ikhtiari1, *, Dyah Wijiana Heryani1, Fiska Maya Wardhani2
1Department of Biomedical Sciences, Faculty of Medicine, Universitas Prima Indonesia, Medan, North Sumatra, 20118, Indonesia
2Department of Medicine, Faculty of Medicine, Universitas Pendidikan Indonesia, Bandung, West Java, 40154, Indonesia
*Corresponding author. Email: refiikhtiari@unprimdn.ac.id
Corresponding Author
Refi Ikhtiari
Available Online 31 March 2025.
DOI
10.2991/978-94-6463-664-2_21How to use a DOI?
Keywords
Bioactive compounds; VEGF; Wound healing; LC-MS/MS
Abstract

This study explores the role of bioactive compounds from Paraboea leuserensis in enhancing vascular endothelial growth factor expression, a critical factor in wound healing. Using liquid chromatography-tandem mass spectrometry, compounds such as quercetin, kaempferol, ellagic acid, myricetin, and betaine were identified and assessed for their biological activity. In vitro assays demonstrated that these compounds promote angiogenesis, regulate inflammation, and enhance extracellular matrix remodeling by influencing key molecular pathways. The findings highlight their ability to stimulate endothelial cell proliferation, migration, and capillary formation, all essential for effective tissue repair. This research underscores the potential of natural products as therapeutic agents for improving wound healing outcomes, particularly in chronic or difficult-to-heal wounds. By elucidating the mechanisms underlying the effects of these bioactive compounds, this study contributes valuable insights into their application in regenerative medicine and natural product-based therapeutic development.

Copyright
© 2025 The Author(s)
Open Access
Open Access This chapter is licensed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License (http://creativecommons.org/licenses/by-nc/4.0/), which permits any noncommercial use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license and indicate if changes were made.

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Volume Title
Proceedings of the 1st International Conference on Lifestyle Diseases and Natural Medicine (ICOLIFEMED 2024)
Series
Advances in Health Sciences Research
Publication Date
31 March 2025
ISBN
978-94-6463-664-2
ISSN
2468-5739
DOI
10.2991/978-94-6463-664-2_21How to use a DOI?
Copyright
© 2025 The Author(s)
Open Access
Open Access This chapter is licensed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License (http://creativecommons.org/licenses/by-nc/4.0/), which permits any noncommercial use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license and indicate if changes were made.

Cite this article

risenwbib
TY  - CONF
AU  - Refi Ikhtiari
AU  - Dyah Wijiana Heryani
AU  - Fiska Maya Wardhani
PY  - 2025
DA  - 2025/03/31
TI  - The Role of Bioactive Compounds from Paraboea leuserensis on VEGF expression of Wound Healing
BT  - Proceedings of the 1st International Conference on Lifestyle Diseases and Natural Medicine (ICOLIFEMED 2024)
PB  - Atlantis Press
SP  - 229
EP  - 238
SN  - 2468-5739
UR  - https://doi.org/10.2991/978-94-6463-664-2_21
DO  - 10.2991/978-94-6463-664-2_21
ID  - Ikhtiari2025
ER  -