Proceedings of the 1st International Conference on Lifestyle Diseases and Natural Medicine (ICOLIFEMED 2024)

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Effectiveness of Andaliman Nanoemulsion Extract on Serum Adiponectin Levels in Male Wistar Rats Induced by Streptozotocin

Authors
Linda Chiuman1, *, Christo Jonathan Silitonga1, Gusbakti Rusip1
1Faculty of Medicine, Dentistry and Health Science, Universitas Prima Indonesia, Medan, Indonesia
*Corresponding author. Email: lindachiuman@unprimdn.ac.id
Corresponding Author
Linda Chiuman
Available Online 31 March 2025.
DOI
10.2991/978-94-6463-664-2_20How to use a DOI?
Keywords
Adiponectin; Andaliman; Diabetes; Hyperglycemia
Abstract

Type 2 diabetes mellitus (T2DM) is a metabolic disorder characterized by insulin resistance and chronic hyperglycemia. Low adiponectin levels are associated with increased T2DM risk. Andaliman, with its antioxidant and anti-inflammatory properties, may influence adiponectin levels and improve insulin sensitivity. This study investigates the effects of andaliman nanoemulsion on adiponectin and blood glucose levels in male Wistar rats. The rats were divided into six groups: normal, negative control, positive control, and three groups treated with andaliman nanoemulsion at doses of 25, 50, and 75 mg/kgBW. Blood glucose was measured before treatment and on days 7, 14, and 21, while adiponectin levels were assessed on day 21 using ELISA. Results showed a significant reduction in blood glucose at the 50 mg/kgBW dose (P<0.05), but no significant differences in adiponectin levels (P>0.05). In conclusion, andaliman nanoemulsion shows promise as an antihyperglycemic agent for T2DM management.

Copyright
© 2025 The Author(s)
Open Access
Open Access This chapter is licensed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License (http://creativecommons.org/licenses/by-nc/4.0/), which permits any noncommercial use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license and indicate if changes were made.

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Volume Title
Proceedings of the 1st International Conference on Lifestyle Diseases and Natural Medicine (ICOLIFEMED 2024)
Series
Advances in Health Sciences Research
Publication Date
31 March 2025
ISBN
978-94-6463-664-2
ISSN
2468-5739
DOI
10.2991/978-94-6463-664-2_20How to use a DOI?
Copyright
© 2025 The Author(s)
Open Access
Open Access This chapter is licensed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License (http://creativecommons.org/licenses/by-nc/4.0/), which permits any noncommercial use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license and indicate if changes were made.

Cite this article

risenwbib
TY  - CONF
AU  - Linda Chiuman
AU  - Christo Jonathan Silitonga
AU  - Gusbakti Rusip
PY  - 2025
DA  - 2025/03/31
TI  - Effectiveness of Andaliman Nanoemulsion Extract on Serum Adiponectin Levels in Male Wistar Rats Induced by Streptozotocin
BT  - Proceedings of the 1st International Conference on Lifestyle Diseases and Natural Medicine (ICOLIFEMED 2024)
PB  - Atlantis Press
SP  - 219
EP  - 228
SN  - 2468-5739
UR  - https://doi.org/10.2991/978-94-6463-664-2_20
DO  - 10.2991/978-94-6463-664-2_20
ID  - Chiuman2025
ER  -