Proceedings of the 1st International Conference on Lifestyle Diseases and Natural Medicine (ICOLIFEMED 2024)

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The Effectiveness of Brown Rice Syrup (Oriza nivara) and Acacia Honey (Acacia carpa) on Uric Acid, Urea, Creatinine Levels and Kidney Histopathology imagery in Alloxan-Induced White Rats (Rattus norvegicus)

Authors
Suandy Suandy1, *, Wira Permadani Nababan1, Andriady Saidi Nasution2
1Department of Biochemistry, Faculty of Medicine, Universitas Prima Indonesia, Medan, Indonesia
2Department of Surgery, Faculty of Medicine, Universitas Prima Indonesia, Medan, Indonesia
*Corresponding author. Email: suandy76@gmail.com
Corresponding Author
Suandy Suandy
Available Online 31 March 2025.
DOI
10.2991/978-94-6463-664-2_28How to use a DOI?
Keywords
uric acid; urea; creatinine; kidney histopathology
Abstract

This study evaluated the effects of Curcuma zedoaria extract on blood glucose, Placental Growth Factor (PlGF), and kidney histopathology in diabetic nephropathy (DN) Wistar rats. DN, a severe diabetic complication, leads to progressive kidney damage. Using a post-test-only control group design, diabetes was induced in male Wistar rats with alloxan, and Curcuma zedoaria extract was administered orally at doses of 250 mg, 500 mg, and 750 mg for two weeks. Blood glucose, PlGF, and kidney histopathology were assessed. Data were analyzed using ANOVA, Kruskal-Wallis, and Bonferroni tests. Results showed significant blood glucose reduction (p < 0.01), with the 750 mg dose being most effective. However, no significant differences were observed in PlGF levels (p = 0.902) or kidney histopathology (p = 0.152). These findings suggest that high-dose Curcuma zedoaria effectively reduces blood glucose in DN, but its effects on PlGF and kidney histopathology are limited.

Copyright
© 2025 The Author(s)
Open Access
Open Access This chapter is licensed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License (http://creativecommons.org/licenses/by-nc/4.0/), which permits any noncommercial use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license and indicate if changes were made.

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Volume Title
Proceedings of the 1st International Conference on Lifestyle Diseases and Natural Medicine (ICOLIFEMED 2024)
Series
Advances in Health Sciences Research
Publication Date
31 March 2025
ISBN
978-94-6463-664-2
ISSN
2468-5739
DOI
10.2991/978-94-6463-664-2_28How to use a DOI?
Copyright
© 2025 The Author(s)
Open Access
Open Access This chapter is licensed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License (http://creativecommons.org/licenses/by-nc/4.0/), which permits any noncommercial use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license and indicate if changes were made.

Cite this article

risenwbib
TY  - CONF
AU  - Suandy Suandy
AU  - Wira Permadani Nababan
AU  - Andriady Saidi Nasution
PY  - 2025
DA  - 2025/03/31
TI  - The Effectiveness of Brown Rice Syrup (Oriza nivara) and Acacia Honey (Acacia carpa) on Uric Acid, Urea, Creatinine Levels and Kidney Histopathology imagery in Alloxan-Induced White Rats (Rattus norvegicus)
BT  - Proceedings of the 1st International Conference on Lifestyle Diseases and Natural Medicine (ICOLIFEMED 2024)
PB  - Atlantis Press
SP  - 306
EP  - 315
SN  - 2468-5739
UR  - https://doi.org/10.2991/978-94-6463-664-2_28
DO  - 10.2991/978-94-6463-664-2_28
ID  - Suandy2025
ER  -