Proceedings of the 1st International Conference on Lifestyle Diseases and Natural Medicine (ICOLIFEMED 2024)

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Hypoglycemic Activity of Pediococcus acidilactici LBSU8 in Experimental Rats with Streptozotocin-Induced Type 2 Diabetes

Authors
Edy Fachrial1, *, Titania T. Nugroho2, Saryono Saryono3, Ismawati Ismawati4
1Doctoral Program of Chemistry, Faculty of Mathematics and Natural Science, Universitas Riau, Pekanbaru, Indonesia
2Faculty of Medicine, Dentistry and Health Sciences, Universitas Prima Indonesia, Medan, Indonesia
3Department of Chemistry, Faculty of Mathematics and Natural Science, Universitas Riau, Pekanbaru, Indonesia
4Department of Biochemistry, Faculty of Medicine, Universitas Riau, Pekanbaru, Indonesia
*Corresponding author.
Corresponding Author
Edy Fachrial
Available Online 31 March 2025.
DOI
10.2991/978-94-6463-664-2_4How to use a DOI?
Keywords
Hypoglycemic activity; Type 2 Diabetes Mellitus; Pediococcus acidilactici LBSU8
Abstract

Type 2 diabetes (T2DM) is a chronic condition marked by insulin resistance and high blood sugar. This study evaluated the hypoglycemic effect of Pediococcus acidilactici strain LBSU8 (PALBSU8), a lactic acid bacterium isolated from buffalo rumen, in streptozotocin (STZ)-induced diabetic rats. PALBSU8 may improve glucose metabolism and insulin sensitivity through mechanisms like short-chain fatty acid (SCFA) production and intestinal barrier modulation. Four groups of Wistar rats received different treatments: Normal control, diabetic (STZ and high-fat diet), positive control (STZ, high-fat diet, and acarbose), and PALBSU8. Postprandial blood glucose was monitored over 21 days. The PALBSU8 group showed significant blood glucose reduction compared to the diabetic group, though levels remained higher than the normal group. Statistical tests (p<0.001) confirmed significant differences, especially in weeks two and three. PALBSU8 demonstrated potential as an alternative probiotic for T2DM management.

Copyright
© 2025 The Author(s)
Open Access
Open Access This chapter is licensed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License (http://creativecommons.org/licenses/by-nc/4.0/), which permits any noncommercial use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license and indicate if changes were made.

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Volume Title
Proceedings of the 1st International Conference on Lifestyle Diseases and Natural Medicine (ICOLIFEMED 2024)
Series
Advances in Health Sciences Research
Publication Date
31 March 2025
ISBN
978-94-6463-664-2
ISSN
2468-5739
DOI
10.2991/978-94-6463-664-2_4How to use a DOI?
Copyright
© 2025 The Author(s)
Open Access
Open Access This chapter is licensed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License (http://creativecommons.org/licenses/by-nc/4.0/), which permits any noncommercial use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license and indicate if changes were made.

Cite this article

risenwbib
TY  - CONF
AU  - Edy Fachrial
AU  - Titania T. Nugroho
AU  - Saryono Saryono
AU  - Ismawati Ismawati
PY  - 2025
DA  - 2025/03/31
TI  - Hypoglycemic Activity of Pediococcus acidilactici LBSU8 in Experimental Rats with Streptozotocin-Induced Type 2 Diabetes
BT  - Proceedings of the 1st International Conference on Lifestyle Diseases and Natural Medicine (ICOLIFEMED 2024)
PB  - Atlantis Press
SP  - 26
EP  - 34
SN  - 2468-5739
UR  - https://doi.org/10.2991/978-94-6463-664-2_4
DO  - 10.2991/978-94-6463-664-2_4
ID  - Fachrial2025
ER  -