Proceedings of the 8th International Conference on Neuroscience, Neurology, and Psychiatry 2025 (ICONAP 2025)

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From Inflammation to Neurovascular Decline: A Review of Cytokine Mechanisms in Dementia and the Role of Donepezil

Authors
Fasihah Irfani Fitri1, *
1Department of Neurology, Faculty of Medicine, Universitas Sumatera Utara, Dr. Mansyur No. 5, Medan, 20155, Sumatera Utara, Indonesia
*Corresponding author. Email: fasihah.irfani@usu.ac.id
Corresponding Author
Fasihah Irfani Fitri
Available Online 25 December 2025.
DOI
10.2991/978-94-6463-966-7_3How to use a DOI?
Keywords
Alzheimer’s disease (AD); inflammatory mechanisms; donepezil
Abstract

Alzheimer’s disease (AD), the most frequent cause of dementia, is a progressive neuro-degenerative condition that affects individuals, families, and health systems worldwide. A increasing body of data links chronic inflammation to the etiology of AD, beyond its typical hallmarks of amyloid-beta (Aβ) plaques and tau neurofibrillar tangles. Proinflammatory cytokines, including IL-1, IL-6, and TNF-α, play a crucial role in the neurodegenerative process. These chemicals cause BBB disintegration, neuronal death, and cognitive impairment. This review highlights the inflammatory pathways involved in AD and examines the role of donepezil, a cholinesterase inhibitor used to treat AD symptoms, which has demonstrated neuroprotective and anti-inflammatory properties. Recent findings suggest that donepezil may modulate neuroinflammation, potentially influencing disease progression.

Copyright
© 2025 The Author(s)
Open Access
Open Access This chapter is licensed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License (http://creativecommons.org/licenses/by-nc/4.0/), which permits any noncommercial use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license and indicate if changes were made.

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Volume Title
Proceedings of the 8th International Conference on Neuroscience, Neurology, and Psychiatry 2025 (ICONAP 2025)
Series
Advances in Health Sciences Research
Publication Date
25 December 2025
ISBN
978-94-6463-966-7
ISSN
2468-5739
DOI
10.2991/978-94-6463-966-7_3How to use a DOI?
Copyright
© 2025 The Author(s)
Open Access
Open Access This chapter is licensed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License (http://creativecommons.org/licenses/by-nc/4.0/), which permits any noncommercial use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license and indicate if changes were made.

Cite this article

risenwbib
TY  - CONF
AU  - Fasihah Irfani Fitri
PY  - 2025
DA  - 2025/12/25
TI  - From Inflammation to Neurovascular Decline: A Review of Cytokine Mechanisms in Dementia and the Role of Donepezil
BT  - Proceedings of the 8th International Conference on Neuroscience, Neurology, and Psychiatry 2025 (ICONAP 2025)
PB  - Atlantis Press
SP  - 16
EP  - 24
SN  - 2468-5739
UR  - https://doi.org/10.2991/978-94-6463-966-7_3
DO  - 10.2991/978-94-6463-966-7_3
ID  - Fitri2025
ER  -