Histological Effects of Black Garlic Extract in Monosodium Glutamate-Exposed Rats

DOI

10.2991/978-94-6239-836-8_2How to use a DOI?

Keywords

Black garlic extract; plant extracts; sodium glutamate; MSG; chemical and drug-induced liver injury; histology

Abstract

The study examined hepatic tissue morphology and liver weight in rats exposed to monosodium glutamate (MSG), with or without black garlic extract (BGE). Twenty-five Wistar rats were assigned at random to five groups of five animals. P0 received no experimental treatment, whereas P1 received MSG at 8 mg/kg body weight daily for 21 days. The remaining groups followed the same MSG schedule and additionally received BGE at 200 (P2), 400 (P3), or 600 (P4) mg/kg body weight for the final 16 days. Liver specimens collected after euthanasia were examined histologically. P2 showed relatively limited cell swelling and cytoplasmic vacuolation, with nuclei remaining centrally located. Lesions in P3 and P4 resembled those in P1. These observations were assessed descriptively, without inferential testing of histological differences. Liver weight varied across groups (one-way ANOVA, p = 0.011); Tukey comparisons identified a higher value in P1 than in P0, while comparisons between P0 and each BGE group were not significant. The tissue observations suggest a possible protective association at 200 mg/kg, but they do not establish a statistically significant histological treatment effect. Quantitative lesion assessment and biochemical measurements are needed to evaluate this preliminary finding.

Copyright

© 2026 The Author(s)

Open Access

Open Access This chapter is licensed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License (http://creativecommons.org/licenses/by-nc/4.0/), which permits any noncommercial use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license and indicate if changes were made.

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TY  - CONF
AU  - Nora Maulina
AU  - Harvina Sawitri
AU  - Cut Sidrah Nadira
AU  - Mulyati Sri Rahayu
AU  - Cut Alia Natasha
AU  - Yulina Dwi Hastuty
AU  - Rahmi Inayati
AU  - Hakim Permana
PY  - 2026
DA  - 2026/11/11
TI  - Histological Effects of Black Garlic Extract in Monosodium Glutamate-Exposed Rats
BT  - Proceedings of the3rd Malikussaleh International Conference on Health and Disaster Medicine 2026  (MICOHEDMED 2026)
PB  - Atlantis Press
SP  - 4
EP  - 13
SN  - 2468-5739
UR  - https://doi.org/10.2991/978-94-6239-836-8_2
DO  - 10.2991/978-94-6239-836-8_2
ID  - Maulina2026
ER  -