Hormonal, Body Composition, and Biochemical Correlates of Menopausal Symptoms in Obese Postmenopausal Women

DOI

10.2991/978-94-6239-807-8_3How to use a DOI?

Keywords

Body Composition; Estradiol; Menopause Rating Scale; Obesity; Tumor Necrosis Factor-alpha

Abstract

Background, Menopausal symptom severity is influenced by hormonal, metabolic, and inflammatory factors; however, their relative contributions remain incompletely understood. This exploratory study investigated the associations of body composition, serum estradiol, total cholesterol, and tumor necrosis factor-alpha (TNF-α) with menopausal symptom severity in obese postmenopausal women. Methods: This exploratory cross-sectional study involved 30 postmenopausal women with obesity aged 50–55 years. Menopausal symptom severity was evaluated with the Menopause Rating Scale (MRS), with body composition and biochemical parameters assessed according to standard procedures. Potential factors related to menopausal symptom severity were explored using correlation and multiple linear regression. Results: Among the variables examined, serum estradiol showed a significant inverse association with total MRS score and remained independently associated with menopausal symptom severity after adjustment for body fat percentage, total cholesterol, and TNF-α (β = −0.688, p < 0.001). The regression model explained 68.0% of the variance in MRS score (adjusted R² = 0.628). Total cholesterol was associated with MRS only in the unadjusted analysis, whereas body composition parameters and TNF-α were not independently associated with menopausal symptom severity. Conclusions: These exploratory findings suggest that serum estradiol may be more closely associated with menopausal symptom severity than body composition, lipid profile, or TNF-α in obese postmenopausal women.

Copyright

© 2026 The Author(s)

Open Access

Open Access This chapter is licensed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License (http://creativecommons.org/licenses/by-nc/4.0/), which permits any noncommercial use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license and indicate if changes were made.

Download article (PDF)

TY  - CONF
AU  - Yhenti Widjayanti
AU  - Budi Santoso
AU  - Purwo Sri Rejeki
PY  - 2026
DA  - 2026/10/24
TI  - Hormonal, Body Composition, and Biochemical Correlates of Menopausal Symptoms in Obese Postmenopausal Women
BT  - Proceedings of the Malang International Conference on Medical and Health Sciences (MICROMEDHS 2026)
PB  - Atlantis Press
SP  - 21
EP  - 29
SN  - 2468-5739
UR  - https://doi.org/10.2991/978-94-6239-807-8_3
DO  - 10.2991/978-94-6239-807-8_3
ID  - Widjayanti2026
ER  -