Preliminary Techno-Economic Analysis of Tuna-Based Collagen Extraction: A Comparison Between Deep Eutectic Solvent and Enzymatic Methods

Puput Liezna Nurlizan; Lina Dong; Safira Candra Asih

doi:10.2991/978-94-6239-717-0_18

<Previous Article In Volume

Next Article In Volume>

Preliminary Techno-Economic Analysis of Tuna-Based Collagen Extraction: A Comparison Between Deep Eutectic Solvent and Enzymatic Methods

Authors

Puput Liezna Nurlizan¹^{, *}, Lina Dong², Safira Candra Asih³

¹Dept of Chem Engineering, Fac of Engineering, Universitas Indonesia, Depok, 1625, Indonesia

²Zhejiang University, Hangzhou, China

³Dept of Chem Engineering, Fac of Engineering, Universitas Indonesia, Depok, 1625, Indonesia

^*Corresponding author. Email: puput.liezna@ui.ac.id

Corresponding Author

Puput Liezna Nurlizan

Available Online 25 June 2026.

DOI: 10.2991/978-94-6239-717-0_18 How to use a DOI?
Keywords: Sustainable extraction; Fish Bone Collagen; Tuna bone byproduct; Natural deep eutectic solvents; Enzyme bromelain
Abstract: This study investigates tuna (Euthynnus affinis) bone by-products as an alternative collagen source to meet Indonesia’s rising demand. Process simulations in SuperPro Designer evaluated two extraction routes: (i) Natural Deep Eutectic Solvents (NaDES) and (ii) bromelain enzyme. Using 337,219 kg raw material annually, results showed NaDES achieved the highest collagen recovery (84.75%) with an IRR of 14.62%, NPV of USD 17.8 million, and PBP of 4.84 years. The bromelain process had lower recovery (54.95%) but better economics (IRR 30.03%, NPV USD 35.7 million, PBP 2.49 years). Overall, bromelain extraction offers higher profitability, while NaDES provides superior recovery and sustainability.
Copyright: © 2026 The Author(s)
Open Access: Open Access This chapter is licensed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License (http://creativecommons.org/licenses/by-nc/4.0/), which permits any noncommercial use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license and indicate if changes were made.

Download article (PDF)

<Previous Article In Volume

Next Article In Volume>

Volume Title: Proceedings of the 19th International Conference on Quality in Research (QiR 2025)
Series: Advances in Engineering Research
Publication Date: 25 June 2026
ISBN: 978-94-6239-717-0
ISSN: 2352-5401
DOI: 10.2991/978-94-6239-717-0_18 How to use a DOI?
Open Access: Open Access This chapter is licensed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License (http://creativecommons.org/licenses/by-nc/4.0/), which permits any noncommercial use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license and indicate if changes were made.

Cite this article

ris enw bib

TY  - CONF
AU  - Puput Liezna Nurlizan
AU  - Lina Dong
AU  - Safira Candra Asih
PY  - 2026
DA  - 2026/06/25
TI  - Preliminary Techno-Economic Analysis of Tuna-Based Collagen Extraction: A Comparison Between Deep Eutectic Solvent and Enzymatic Methods
BT  - Proceedings of the 19th International Conference on Quality in Research (QiR 2025)
PB  - Atlantis Press
SP  - 240
EP  - 256
SN  - 2352-5401
UR  - https://doi.org/10.2991/978-94-6239-717-0_18
DO  - 10.2991/978-94-6239-717-0_18
ID  - Nurlizan2026
ER  -

download .riscopy to clipboard