Proceedings of the 19th International Conference on Quality in Research (QiR 2025)

19th International Conference on Quality in Research (QiR 2025)

📍Yogyakarta, IndonesiađŸ—“ïž 27-28 October 2025
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Sustained Calcium Ion Release from Gelatin-Monetite Composite Sponges for Hemostatic Applications

Authors
Azizah Intan Pangesty1, *, M. Naufal Misbah1, M. Akif Tholibul Huda1, Sunarso2, Abdul Halim Abdullah3, Myrna Nurlatifah Zakaria4
1Department of Metallurgical and Material Sciences, Faculty of Engineering, Universitas Indonesia, Depok, Indonesia
2Department of Dental Materials, Faculty of Dentistry, Universitas Indonesia, Depok, Indonesia
3School of Mechanical Engineering, College of Engineering, Universiti Teknologi MARA, 40450, Shah Alam, Selangor, Malaysia
4Department of Restorative Dentistry, College of Dentistry, Ajman University, Ajman, P.O.Box 346, UAE
*Corresponding author. Email: azizah.ip@ui.ac.id
Corresponding Author
Azizah Intan Pangesty
Available Online 25 June 2026.
DOI
10.2991/978-94-6239-717-0_24How to use a DOI?
Keywords
Hemostasis; Gelatin Sponge; Monetite (CaHPO4); Ca ion release; Biocompatibility
Abstract

Uncontrolled bleeding (hemorrhage) remains a critical concern in trauma and surgical settings, often leading to multi-organ failure and mortality. Gelatin-based sponges are widely used as hemostatic agents due to their excellent biocompatibility and fluid absorption capabilities. However, their functionality can be further improved. This study explores the enhancement of gelatin sponges by incorporating monetite (CaHPO₄), a calcium-based compound known to stimulate coagulation through sustained calcium ion (Ca2âș) release. Composite sponges containing 3%, 5%, and 10% monetite were fabricated via freeze-drying. All samples exhibited interconnected porous networks (350–700 ”m) and homogeneously dispersed monetite particles (5–20 ”m). Increasing monetite concentration reduced porosity, which affected both swelling behavior and degradation kinetics. Swelling ratios for 0%, 3%, 5%, and 10% monetite sponges were 1000%, 1300%, 1000%, and 900%, respectively. The addition of monetite significantly slowed degradation, extending the material’s structural integrity up to 48 hours. Calcium release was sustained, increasing from 1.3 ppm at 15 minutes to 2.0 ppm at 60 minutes. In vitro cytocompatibility assessment using the MTT assay showed over 80% cell viability for all groups. These results suggest that gelatin-monetite sponges combine structural durability with pro-coagulant ion release, offering a biocompatible and effective hemostatic material for rapid intervention in severe bleeding scenarios.

Copyright
© 2026 The Author(s)
Open Access
Open Access This chapter is licensed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License (http://creativecommons.org/licenses/by-nc/4.0/), which permits any noncommercial use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license and indicate if changes were made.

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Volume Title
Proceedings of the 19th International Conference on Quality in Research (QiR 2025)
Series
Advances in Engineering Research
Publication Date
25 June 2026
ISBN
978-94-6239-717-0
ISSN
2352-5401
DOI
10.2991/978-94-6239-717-0_24How to use a DOI?
Copyright
© 2026 The Author(s)
Open Access
Open Access This chapter is licensed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License (http://creativecommons.org/licenses/by-nc/4.0/), which permits any noncommercial use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license and indicate if changes were made.

Cite this article

risenwbib
TY  - CONF
AU  - Azizah Intan Pangesty
AU  - M. Naufal Misbah
AU  - M. Akif Tholibul Huda
AU  - Sunarso
AU  - Abdul Halim Abdullah
AU  - Myrna Nurlatifah Zakaria
PY  - 2026
DA  - 2026/06/25
TI  - Sustained Calcium Ion Release from Gelatin-Monetite Composite Sponges for Hemostatic Applications
BT  - Proceedings of the 19th International Conference on Quality in Research (QiR 2025)
PB  - Atlantis Press
SP  - 331
EP  - 347
SN  - 2352-5401
UR  - https://doi.org/10.2991/978-94-6239-717-0_24
DO  - 10.2991/978-94-6239-717-0_24
ID  - Pangesty2026
ER  -