Exosome Dynamics in Aging and Age-Related Therapies

DOI

10.2991/978-94-6463-813-4_15How to use a DOI?

Keywords

Cellular Senescence; Exosomes; Intercellular Communication; Age-Related Diseases; Therapeutic Potential

Abstract

Cellular senescence, characterized by the indefinite division of cells, is a key contributor to age-related diseases. Senescent cells release bioactive molecules, including exosomes that communicate with each other. These small extracellular vesicles have a dual role, either promoting or inhibiting certain aspects of cellular senescence, which has rendered them an interesting area of investigation for potential therapies. This article offers an overview of cellular senescence, emphasizing how exosomes influence its regulation and their possible therapeutic uses. Exosomes release traits that antagonize senescence through gene expression modulation, modulation of mitochondrial activity, and modulation of inflammation. It also elaborates on the application against a plethora of diseases like osteoarthritis, cardiovascular diseases, and neurodegenerative diseases that eagerly await its applicability in therapies. Despite the enormous promise of the therapies based on exosomes, several challenges had impeded their transition into the clinical phase. Multiple factors need to be taken into consideration: heterogeneity; problems with separation and purification; delivery circumstances; and toxicity considerations. Specific barriers must be overcome for each therapeutic application. Many of these challenges may be addressed by bioengineering further target delivery and purification. Furthermore, greater insight into exosome generation and function would undoubtedly be crucial for unlocking some of the potential. Exosomes offer a likely avenue for tackling aging and related diseases. If approved, they may open doors for staggering, life-giving therapies for healthy aging, with reduced burdens of degenerative disease. Moreover, in regenerative medicine, their putative applications could introduce curricula changes in the future therapies for age-related diseases.

Copyright

© 2025 The Author(s)

Open Access

Open Access This chapter is licensed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License (http://creativecommons.org/licenses/by-nc/4.0/), which permits any noncommercial use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license and indicate if changes were made.

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TY  - CONF
AU  - Samudrala Lahari
AU  - Y. Sneha
AU  - Chitti Sathwika
AU  - Meghavath Tharun
AU  - Bhanu Pratap Singh
AU  - T. Rama Rao
PY  - 2025
DA  - 2025/08/13
TI  - Exosome Dynamics in Aging and Age-Related Therapies
BT  - Proceedings of the International symposium on Sustainable Drug Design and Nanoparticle development: Quantum and Computational Perspectives (SDDNDQCP 2025)
PB  - Atlantis Press
SP  - 210
EP  - 227
SN  - 2468-5739
UR  - https://doi.org/10.2991/978-94-6463-813-4_15
DO  - 10.2991/978-94-6463-813-4_15
ID  - Lahari2025
ER  -