Proceedings of the International symposium on Sustainable Drug Design and Nanoparticle development: Quantum and Computational Perspectives (SDDNDQCP 2025)

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Optimizing PPI Therapy: A Comprehensive Approach to ADR Identification, Cost Minimization, and Patient Awareness

Authors
B. Pamula Reddy1, S. K. Faizan Ali2, Mallela Maharshi2, A. G. N. Harshitha Devi2, *, A. Devika2, T. P. Santosh Kumar2
1Department of Pharmaceutics, Nirmala College of Pharmacy, Atmakur, Mangalagiri, Guntur, Andhra Pradesh, India
2Department of Pharmacology and Pharmacy Practice, Nirmala College of Pharmacy, Atmakur, Mangalagiri, Guntur, Andhra Pradesh, India
*Corresponding author. Email: adivishnuharshi@gmail.com
Corresponding Author
A. G. N. Harshitha Devi
Available Online 13 August 2025.
DOI
10.2991/978-94-6463-813-4_16How to use a DOI?
Keywords
Adverse Drug Reactions; Cost-Minimization Analysis; Proton Pump Inhibitors
Abstract

Proton Pump Inhibitors (PPIs) are commonly prescribed for the treatment of acid-related disorders; however, prolonged use of these medications is associated with various adverse drug reactions (ADRs) that can have significant implications for patient health. This prospective observational study was conducted at a tertiary care hospital from June to November 2024. 400 patients were observed. The objective of this study were to perform a cost-minimization analysis by comparing the branded and generic PPIs of both Intravenous and oral route of administration, and also to identify Adverse drug reactions associated with Proton Pump Inhibitors. The cost- minimization analysis was performed through t-test by using SPSS-16 software. The results shows that the use of generic Proton Pump Inhibitors was found to be more economical. A novel “Proton Pump Inhibitor Adverse Drug Reaction Awarenesss and Severity Scoring Matrix” was developed as part of this study. This scale was uniquely employed in scoring awareness of patients of Adverse drug reactions caused by PPIs.

Copyright
© 2025 The Author(s)
Open Access
Open Access This chapter is licensed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License (http://creativecommons.org/licenses/by-nc/4.0/), which permits any noncommercial use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license and indicate if changes were made.

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Volume Title
Proceedings of the International symposium on Sustainable Drug Design and Nanoparticle development: Quantum and Computational Perspectives (SDDNDQCP 2025)
Series
Advances in Health Sciences Research
Publication Date
13 August 2025
ISBN
978-94-6463-813-4
ISSN
2468-5739
DOI
10.2991/978-94-6463-813-4_16How to use a DOI?
Copyright
© 2025 The Author(s)
Open Access
Open Access This chapter is licensed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License (http://creativecommons.org/licenses/by-nc/4.0/), which permits any noncommercial use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license and indicate if changes were made.

Cite this article

risenwbib
TY  - CONF
AU  - B. Pamula Reddy
AU  - S. K. Faizan Ali
AU  - Mallela Maharshi
AU  - A. G. N. Harshitha Devi
AU  - A. Devika
AU  - T. P. Santosh Kumar
PY  - 2025
DA  - 2025/08/13
TI  - Optimizing PPI Therapy: A Comprehensive Approach to ADR Identification, Cost Minimization, and Patient Awareness
BT  - Proceedings of the International symposium on Sustainable Drug Design and Nanoparticle development: Quantum and Computational Perspectives (SDDNDQCP 2025)
PB  - Atlantis Press
SP  - 228
EP  - 240
SN  - 2468-5739
UR  - https://doi.org/10.2991/978-94-6463-813-4_16
DO  - 10.2991/978-94-6463-813-4_16
ID  - Reddy2025
ER  -