Current Understanding of The Mechanisms Underlying Diabetic Wounds

DOI

10.2991/978-94-6463-813-4_24How to use a DOI?

Keywords

Diabetic Wound; Pathophysiology; Hyperglycaemia; Fibroblasts; Keratinocytes; Gene Therapies; Nanotechnology

Abstract

Diabetic wounds, a severe consequence among diabetic patients, significantly contribute to disability and mortality. A significant part of this work on the pathophysiology of diabetic wound healing has mostly focused on processes driven by chronic inflammation, hyperglycaemia and dysfunctions in microcirculation. As per the recent research, defensins could have an important part in the initiation and maintenance of diabetic wound healing. Chronic, non-healing process, particularly in the lower limbs, are the result of diabetes's obstruction of various stages of the wound healing. Diabetes-related hyperglycemia disrupts the regular operation of vital cells such fibroblasts, keratinocytes and endothelial cells that participate in the healing of serious wounds. Mononeuropathy, commonly seen in diabetic individuals, impairs diabetic wound healing by reducing pain sensitivity, making injuries go unnoticed and worsening progressively. Diabetic wounds are also more risk of infection due to a weakened immune response, further delaying healing and increasing the risk of severe complications like amputation or gangrene. Recent study into the molecular and cellular processes of diabetic wound healing has led to the development of new treatment approaches, including stem cell therapy, growth factors and bioengineered skin substitutes to promote tissue regeneration. In addition, advanced treatments like nanotechnology and gene therapy offer targeted interventions for better healing outcomes. Managing diabetic wounds functionally requires a comprehensive strategy involving glucose control, infection management, and modern wound care practices. Ongoing study is very crucial for discovering innovative therapies that improve the standard of care and patient outcomes in diabetes.

Copyright

© 2025 The Author(s)

Open Access

Open Access This chapter is licensed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License (http://creativecommons.org/licenses/by-nc/4.0/), which permits any noncommercial use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license and indicate if changes were made.

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TY  - CONF
AU  - Arindam Kolay
AU  - Ravindra Pal Singh
AU  - Rewak Tyagi
AU  - Prashant Regar
AU  - Shivam Singh
PY  - 2025
DA  - 2025/08/13
TI  - Current Understanding of The Mechanisms Underlying Diabetic Wounds
BT  - Proceedings of the International symposium on Sustainable Drug Design and Nanoparticle development: Quantum and Computational Perspectives (SDDNDQCP 2025)
PB  - Atlantis Press
SP  - 317
EP  - 328
SN  - 2468-5739
UR  - https://doi.org/10.2991/978-94-6463-813-4_24
DO  - 10.2991/978-94-6463-813-4_24
ID  - Kolay2025
ER  -