Brassica nigra L., A Potential Hepatoprotective and Anti Tuberculosis Agent

DOI

10.2991/978-94-6463-813-4_25How to use a DOI?

Keywords

HABN; Anti tuberculosis activity; Assessment of liver function; DNA repair mechanisms; tissue histopathology; antioxidant activity; lipid oxidative degradation

Abstract

In clinical background, an anti-tuberculosis medication that may harm the liver. The medicinal plant Brassica nigra L (Brassicaceae) has anticancer and antioxidant properties. Brassica nigra L. hydroalcoholic extracts were screened for antitubercular activity using the NRA and BacT/Alert methods. It was investigated whether the hydroalcoholic extract of Brassica nigra L seeds could protect mice’s livers from RIPE-induced hepatotoxicity. A total of eight animals were randomly allocated to six different groups. To induce liver damage, a specific dosage blend of RIPE was prescribed for a duration of fifteen days, Various treatments, including HABN and RIPE combined with Sylmarin, were ran to the treatment sets prior to the introduction of RIPE. The control group got 2% DMSO. Studies were conducted on tissue antioxidant enzymes, DNA damage, serum liver function tests, and histopathological changes. The results of HABN and Standard Sylmarin, which are based on M. tuberculosis’s capacity to vary in colour, were disclosed by NRA in the current investigation. The hydroalcoholic extract of Brassica nigra and Standard Sylmarin significantly increased rat liver and body mass (P < 0.1) compared to animals given RIPE. Furthermore, RIPE not only heightened DNA fragmentation (P < 0.001) but also reduced lipid levels and raised the serum levels of lactate dehydrogenase (LDH), AST, γ-GT. By increasing the ratio of antioxidants to oxidants, HABN treatment prevents oxidative damage caused by RIPE. Biochemical results are grasped by histological investigation. The study demonstrated that HABN’s antioxidant.

Copyright

© 2025 The Author(s)

Open Access

Open Access This chapter is licensed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License (http://creativecommons.org/licenses/by-nc/4.0/), which permits any noncommercial use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license and indicate if changes were made.

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TY  - CONF
AU  - Supriya Chatla
AU  - M. Lakshmi Santha
AU  - A. Suneetha
AU  - B. Sravani
AU  - B. Shriya Suzan
AU  - Ch. Bindu Madhuri
PY  - 2025
DA  - 2025/08/13
TI  - Brassica nigra L., A Potential Hepatoprotective and Anti Tuberculosis Agent
BT  - Proceedings of the International symposium on Sustainable Drug Design and Nanoparticle development: Quantum and Computational Perspectives (SDDNDQCP 2025)
PB  - Atlantis Press
SP  - 329
EP  - 344
SN  - 2468-5739
UR  - https://doi.org/10.2991/978-94-6463-813-4_25
DO  - 10.2991/978-94-6463-813-4_25
ID  - Chatla2025
ER  -