Proceedings of the Turakulov Readings 2025 Conference (TR 2025)

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Clinical Observations of Elevated ACTH Levels, Hyperinsulinemia, and Hypothyroidism Before and After Bariatric Surgery

Authors
Anvar Valiyevich Aliyev1, Shakhlo Takhirjanovna Muratova1, Gulrukh Aybekovna Alimuhamedova1, Sakhobat Mukhsiym qizi Makhmudova1, *, Khurshida Tavakkalovna Sultonova1
1Y.X. Turakulov Republican Specialized Scientific and Practical Medical Center of Endocrinology, Tashkent, Republic of Uzbekistan
*Corresponding author. Email: maxmudovasaxovatmuxsimqizi@mail.ru
Corresponding Author
Sakhobat Mukhsiym qizi Makhmudova
Available Online 26 December 2025.
DOI
10.2991/978-94-6463-984-1_8How to use a DOI?
Keywords
Clinical observation; ACTH Levels; Hyperinsulinemia; Hypothyroidism; Bariatric Surgery
Abstract

Elevated ACTH levels have been observed in obese patient with hyperinsulinemia, potentially contributing to hypothyroid-like states through impaired T4-to-T3 conversion. We present the case of an 18-year-old female with a long-standing history of obesity (BMI: 47 kg/m2), hyperphagia, and symptoms consistent with hypothyroidism and hyperandrogenism. Laboratory tests revealed elevated ACTH (109.6 pg/mL), insulin (185.18 μIU/mL), and TSH (5.857 μIU/mL), with decreased free T3 (2.4 pg/mL) levels, indicating subclinical hypothyroidism. The patient underwent bariatric surgery in April 2024. Three months postoperatively, significant clinical improvements were observed, including a 28.3% total weight loss and 60.6% excess weight loss. Follow-up hormonal analysis showed normalized insulin (17.9 μIU/mL), decreased ACTH and TSH levels, and increased free T3 (3.1 pg/mL). This case highlights the potential reversibility of ACTH-driven subclinical hypothyroidism and hyperphagia in the context of obesity-related insulin resistance following bariatric surgery. Weight loss can lead to substantial hormonal rebalancing and improved metabolic function.

Copyright
© 2025 The Author(s)
Open Access
Open Access This chapter is licensed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License (http://creativecommons.org/licenses/by-nc/4.0/), which permits any noncommercial use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license and indicate if changes were made.

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Volume Title
Proceedings of the Turakulov Readings 2025 Conference (TR 2025)
Series
Advances in Health Sciences Research
Publication Date
26 December 2025
ISBN
978-94-6463-984-1
ISSN
2468-5739
DOI
10.2991/978-94-6463-984-1_8How to use a DOI?
Copyright
© 2025 The Author(s)
Open Access
Open Access This chapter is licensed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License (http://creativecommons.org/licenses/by-nc/4.0/), which permits any noncommercial use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license and indicate if changes were made.

Cite this article

risenwbib
TY  - CONF
AU  - Anvar Valiyevich Aliyev
AU  - Shakhlo Takhirjanovna Muratova
AU  - Gulrukh Aybekovna Alimuhamedova
AU  - Sakhobat Mukhsiym qizi Makhmudova
AU  - Khurshida Tavakkalovna Sultonova
PY  - 2025
DA  - 2025/12/26
TI  - Clinical Observations of Elevated ACTH Levels, Hyperinsulinemia, and Hypothyroidism Before and After Bariatric Surgery
BT  - Proceedings of the Turakulov Readings 2025 Conference (TR 2025)
PB  - Atlantis Press
SP  - 77
EP  - 84
SN  - 2468-5739
UR  - https://doi.org/10.2991/978-94-6463-984-1_8
DO  - 10.2991/978-94-6463-984-1_8
ID  - Aliyev2025
ER  -