The Influence of Hyperthyroidism on the Psycho-Emotional and Intellectual Status of Children Living in Iodine-Deficient Regions of the Republic of Uzbekistan

DOI

10.2991/978-94-6463-984-1_7How to use a DOI?

Keywords

anxiety; intelligence; IQ; hyperthyroidism; Graves’ disease; children; adolescents

Abstract

Neurogenesis continues until approximately 25 years of age; however, only a limited number of studies have investigated the neurobehavioral consequences of hyperthyroidism in children and adolescents. The effects of hyperthyroidism on cognitive and intellectual development remain insufficiently studied, particularly in iodine-deficient regions. This research aims to evaluate the impact of hyperthyroidism on anxiety levels and intellectual performance (IQ) in children and adolescents. A total of 146 children with hyperthyroidism and 97 healthy controls were included. Clinical and anamnestic evaluation, as well as biochemical and hormonal assessments (TSH, free/total T3, free/total T4, anti-TPO, AT-rTSH), were performed. Anxiety levels were assessed using Spielberger’s State-Trait Personality Inventory (STPI), and cognitive function was evaluated using Raven’s Progressive Matrices. The result shows that children with hyperthyroidism demonstrated significantly higher anxiety and irritability, along with reduced cognitive engagement. Their mean IQ was 25 points lower compared with the control group (p < 0.001). Most affected children displayed average or below-average intellectual performance. Significant correlations were observed between anxiety, cognitive engagement, and levels of free T4, AT-rTSH, vitamin D, and TSH. Receiver operating characteristic (ROC) analysis identified free T3, vitamin D < 20 ng/mL, and AT-rTSH ≥ 30 U as predictive markers of cognitive impairment. Hyperthyroidism exerts a negative impact on anxiety, cognitive function, and intellectual performance in children residing in iodine-deficient regions of Uzbekistan. Large-scale prospective studies are warranted to further clarify the long-term effects.

Copyright

© 2025 The Author(s)

Open Access

Open Access This chapter is licensed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License (http://creativecommons.org/licenses/by-nc/4.0/), which permits any noncommercial use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license and indicate if changes were made.

Download article (PDF)

TY  - CONF
AU  - Sh. T. Muratova
AU  - A. V. Alimova
PY  - 2025
DA  - 2025/12/26
TI  - The Influence of Hyperthyroidism on the Psycho-Emotional and Intellectual Status of Children Living in Iodine-Deficient Regions of the Republic of Uzbekistan
BT  - Proceedings of the Turakulov Readings 2025 Conference (TR 2025)
PB  - Atlantis Press
SP  - 64
EP  - 76
SN  - 2468-5739
UR  - https://doi.org/10.2991/978-94-6463-984-1_7
DO  - 10.2991/978-94-6463-984-1_7
ID  - Muratova2025
ER  -