Proceedings of the Turakulov Readings 2025 Conference (TR 2025)

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Clinical and Hormonal Characteristics and Quality of Life in Patients with Obesity: The Role of Somatotropic Axis Deficiency

Authors
A. O. Kholikova1, A. R. Rakhimova1, X. M. Saatova1, A. U. Abdullaeva1, *
1Republican Specialized Scientific and Practical Medical Center of Endocrinology named after Academician Yo.Kh. Turakulov, Tashkent, Uzbekistan
*Corresponding author. Email: azizka.94@mail.ru
Corresponding Author
A. U. Abdullaeva
Available Online 26 December 2025.
DOI
10.2991/978-94-6463-984-1_6How to use a DOI?
Keywords
obesity; growth hormone; IGF-1; QoL-AGHDA; quality of life
Abstract

The study aims to investigate anthropometric parameters, hormonal indicators, and quality of life in patients with obesity, with a focus on somatotropic function. The study included 800 patients with obesity and 20 healthy individuals in the control group. Anthropometric measurements (BMI, waist-to-hip ratio), hormonal assessments (GH, IGF-1, TSH, free T4), and a quality-of-life survey using the QoL-AGHDA scale were conducted. Patients with obesity demonstrated significantly higher BMI values (31.2 ± 3.1 vs. 24.0 ± 2.2 kg/m2, p<0.001) and waist-to-hip ratio (0.89–0.92 vs. 0.82, p<0.001). Somatotropic function was markedly impaired: peak GH levels were more than twofold lower, and IGF-1 levels were almost twice as low compared to controls (p<0.001). Thyroid function parameters (TSH, free T4) remained within normal ranges and showed no statistically significant differences between groups. According to the QoL-AGHDA scale, patients reported lower quality of life than controls, particularly among women (p<0.001). Obese patients are characterized by a pronounced deficiency of the somatotropic axis while maintaining normal thyroid function, which is accompanied by reduced quality of life. Comprehensive clinical and hormonal monitoring with a focus on identifying somatotropic deficiency is essential.

Copyright
© 2025 The Author(s)
Open Access
Open Access This chapter is licensed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License (http://creativecommons.org/licenses/by-nc/4.0/), which permits any noncommercial use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license and indicate if changes were made.

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Volume Title
Proceedings of the Turakulov Readings 2025 Conference (TR 2025)
Series
Advances in Health Sciences Research
Publication Date
26 December 2025
ISBN
978-94-6463-984-1
ISSN
2468-5739
DOI
10.2991/978-94-6463-984-1_6How to use a DOI?
Copyright
© 2025 The Author(s)
Open Access
Open Access This chapter is licensed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License (http://creativecommons.org/licenses/by-nc/4.0/), which permits any noncommercial use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license and indicate if changes were made.

Cite this article

risenwbib
TY  - CONF
AU  - A. O. Kholikova
AU  - A. R. Rakhimova
AU  - X. M. Saatova
AU  - A. U. Abdullaeva
PY  - 2025
DA  - 2025/12/26
TI  - Clinical and Hormonal Characteristics and Quality of Life in Patients with Obesity: The Role of Somatotropic Axis Deficiency
BT  - Proceedings of the Turakulov Readings 2025 Conference (TR 2025)
PB  - Atlantis Press
SP  - 52
EP  - 63
SN  - 2468-5739
UR  - https://doi.org/10.2991/978-94-6463-984-1_6
DO  - 10.2991/978-94-6463-984-1_6
ID  - Kholikova2025
ER  -