Pharmacological Approach on Efficacy and Safety Aspects of Proton Pump Inhibitors in the Elderly: A Narrative Review

DOI

10.2991/978-94-6239-762-0_21How to use a DOI?

Keywords

Proton Pump Inhibitor; Elderly; Efficacy; Safety

Abstract

Proton pump inhibitors (PPIs) are among the most widely utilized medications globally. Their use in elderly individuals is recommended for the management of gastrointestinal disorders, as well as for prophylactic purposes to mitigate adverse effects associated with certain medications. The prevalence of PPI use has increased significantly among elderly patients. This study aims to provide a comprehensive review of the mechanism of action, pharmacokinetics, efficacy, and safety of PPIs in the elderly population. PubMed, Google Scholar, and Cochrane databases were searched until November 2024. Original studies investigating the efficacy, safety, and pharmacological properties of PPIs were explicitly emphasized. Publications not written in English were excluded. Alterations in the pharmacokinetic characteristics of PPIs in the elderly, linked to bioavailability, plasma clearance, and reduced albumin levels, may diminish efficacy or heighten the risk of toxicity. PPIs are linked to a reduction in the incidence of first-time ischemic stroke and enhancement of nutritional status in the elderly. The safety of PPI use is linked to the risk of Clostridioides difficile infection (CDI), fractures, dementia, depression, negative inotropic effects, and increased cancer susceptibility. Clinicians must evaluate the legitimate indications prior to administering PPIs and their detrimental consequences on the health of the elderly.

Copyright

© 2026 The Author(s)

Open Access

Open Access This chapter is licensed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License (http://creativecommons.org/licenses/by-nc-nd/4.0/), which permits any noncommercial use, sharing, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license and indicate if you modified the licensed material. You do not have permission under this license to share adapted material derived from this chapter or parts of it.

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TY  - CONF
AU  - Thendi Abdul Arief
AU  - Nabila Risti Rachmadi
AU  - Hanum Hasifah Fahriah
AU  - Agung Endro Nugroho
PY  - 2026
DA  - 2026/09/04
TI  - Pharmacological Approach on Efficacy and Safety Aspects of Proton Pump Inhibitors in the Elderly: A Narrative Review
BT  - Proceedings of the 6th International Conference on Bioinformatics, Biotechnology, and Biomedical Engineering (BIOMIC 2025)
PB  - Atlantis Press
SP  - 319
EP  - 349
SN  - 2468-5739
UR  - https://doi.org/10.2991/978-94-6239-762-0_21
DO  - 10.2991/978-94-6239-762-0_21
ID  - Arief2026
ER  -