Proceedings of the 6th International Conference on Bioinformatics, Biotechnology, and Biomedical Engineering (BIOMIC 2025)

6th International Conference on Bioinformatics, Biotechnology, and Biomedical Engineering (BIOMIC 2025)

📍Yogyakarta, Indonesia🗓️ 30-31 July 2025
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Network Pharmacology and Molecular Docking-Based Investigation of Mesui (Cryptocarya massoy) in the Management of Delayed-Onset Muscle Soreness

Authors
I Gusti Agung Ayu Kartika1, Kevin Awidarta2, Sisca Ucche2, Agung Endro Nugroho2, *
1Yoga and Health Study Program, Faculty of Brahma Widya, I Gusti Bagus Sugriwa Denpasar State Hindu University, Bali, 80239, Indonesia
2Department of Pharmacology and Clinical Pharmacy, Faculty of Pharmacy, Universitas Gadjah Mada, Yogyakarta, 55281, Indonesia
*Corresponding author. Email: nugroho_ae@ugm.ac.id
Corresponding Author
Agung Endro Nugroho
Available Online 4 September 2026.
DOI
10.2991/978-94-6239-762-0_32How to use a DOI?
Keywords
Delayed-Onset Muscle Soreness; Cryptocarya massoy; Network Pharmacology; PTGS2; Molecular Docking
Abstract

Delayed-onset muscle soreness (DOMS) is a condition that occurs after exercise and is characterized by muscle pain, stiffness, and decreased functionality. Traditional therapies such as NSAIDs often have limitations owing to their adverse effects and variable effectiveness. This study aimed to investigate the molecular mechanisms by which Cryptocarya massoy alleviates DOMS, using an integrated approach involving network pharmacology and molecular docking. This study identified 26 phytoconstituents in C. massoy, 14 of which met the drug-likeness and bioavailability criteria, indicating 24 potential therapeutic targets for DOMS. TNF signaling and inflammation-related pathways have been identified as key mechanisms. Prostaglandin G/H synthase 2 (PTGS2) was identified as a central protein target. The 1,2-benzenedicarboxylic acid-butyl phenylmethyl ester demonstrated the highest binding affinity to PTGS2, surpassing that of mefenamic acid. This compound exhibited stable interactions with key residues, indicating its anti-inflammatory potential. This study suggests the potential application of C. massoy as a natural therapeutic agent for DOMS, with primary compounds potentially functioning through the multi-target modulation of inflammatory signaling pathways, particularly through the inhibition of PTGS2.

Copyright
© 2026 The Author(s)
Open Access
Open Access This chapter is licensed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License (http://creativecommons.org/licenses/by-nc-nd/4.0/), which permits any noncommercial use, sharing, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license and indicate if you modified the licensed material. You do not have permission under this license to share adapted material derived from this chapter or parts of it.

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Volume Title
Proceedings of the 6th International Conference on Bioinformatics, Biotechnology, and Biomedical Engineering (BIOMIC 2025)
Series
Advances in Health Sciences Research
Publication Date
4 September 2026
ISBN
978-94-6239-762-0
ISSN
2468-5739
DOI
10.2991/978-94-6239-762-0_32How to use a DOI?
Copyright
© 2026 The Author(s)
Open Access
Open Access This chapter is licensed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License (http://creativecommons.org/licenses/by-nc-nd/4.0/), which permits any noncommercial use, sharing, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license and indicate if you modified the licensed material. You do not have permission under this license to share adapted material derived from this chapter or parts of it.

Cite this article

risenwbib
TY  - CONF
AU  - I Gusti Agung Ayu Kartika
AU  - Kevin Awidarta
AU  - Sisca Ucche
AU  - Agung Endro Nugroho
PY  - 2026
DA  - 2026/09/04
TI  - Network Pharmacology and Molecular Docking-Based Investigation of Mesui (Cryptocarya massoy) in the Management of Delayed-Onset Muscle Soreness
BT  - Proceedings of the 6th International Conference on Bioinformatics, Biotechnology, and Biomedical Engineering (BIOMIC 2025)
PB  - Atlantis Press
SP  - 516
EP  - 532
SN  - 2468-5739
UR  - https://doi.org/10.2991/978-94-6239-762-0_32
DO  - 10.2991/978-94-6239-762-0_32
ID  - Kartika2026
ER  -