The Potency of Chalcone Derivatives as Anticancer Agents: A Five-Decade Bibliometric Overview

Fitriana Nur Hanifah; Indah Zunita Sari; Salsabilla Kristinawati; Alma Nur Azizah; Jeesica Hermayanti Pratama; Ratna Asmah Susidarti; Umah Rani Kuppusamy

doi:10.2991/978-94-6239-762-0_31

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The Potency of Chalcone Derivatives as Anticancer Agents: A Five-Decade Bibliometric Overview

Authors

Fitriana Nur Hanifah¹^{, 2}, Indah Zunita Sari², Salsabilla Kristinawati², Alma Nur Azizah², Jeesica Hermayanti Pratama³, Ratna Asmah Susidarti¹^{, 4}^{, *}, Umah Rani Kuppusamy⁵

¹Cancer Chemoprevention Research Center, Faculty of Pharmacy, Universitas Gadjah Mada, Yogyakarta, 55281, Indonesia

²Master Program of Pharmaceutical Sciences, Faculty of Pharmacy, Universitas Gadjah Mada, Yogyakarta, 55281, Indonesia

³Department of Chemistry, Faculty of Science and Data Analytics, Institut Teknologi Sepuluh Nopember, Surabaya, 60111, Indonesia

⁴Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Universitas Gadjah Mada, Yogyakarta, 55281, Indonesia

⁵Department of Biomedical Sciences, Faculty of Medicine, Universiti Malaya, Kuala Lumpur, 50603, Malaysia

^*Corresponding author. Email: ratna_asmah@ugm.ac.id

Corresponding Author

Ratna Asmah Susidarti

Available Online 4 September 2026.

DOI: 10.2991/978-94-6239-762-0_31 How to use a DOI?
Keywords: Chalcone Derivatives; Anticancer; Bibliometric Analysis; Research Trends; Hotspot
Abstract: Cancer continues to pose a considerable global health challenge, as traditional therapies such as chemotherapy and radiotherapy are frequently constrained by drug resistance and detrimental side effects. Natural compounds such as chalcones have attracted interest for their potential as anticancer agents owing to their selective cytotoxicity. The chemical structure of chalcones can be readily modified to improve their biological activity. Chalcone derivatives exhibit anticancer properties via various mechanisms, such as apoptosis induction, reactive oxygen species generation, mitochondrial dysfunction, tubulin inhibition, and transcription factor modulation. Despite the increasing amount of research on chalcone derivatives, a comprehensive bibliometric analysis assessing research trends, hotspots, and international collaborations in this field is yet to be conducted. This study fills the gap by examining 1,269 articles from the Scopus database utilizing the keywords “chalcone derivatives” and “anticancer”. The data were analyzed using VOSviewer and Biblioshiny (RStudio) to investigate publication trends, keyword mapping, prolific journals, countries, institutions, and authors, also collaboration networks. Additionally, this study briefly reviews the synthetic approaches and mechanisms underlying the anticancer activity of chalcone derivatives. These findings aim to direct future research trends and enhance innovations in the development of chalcone-based anticancer therapies.
Open Access: Open Access This chapter is licensed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License (http://creativecommons.org/licenses/by-nc-nd/4.0/), which permits any noncommercial use, sharing, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license and indicate if you modified the licensed material. You do not have permission under this license to share adapted material derived from this chapter or parts of it.

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Volume Title: Proceedings of the 6th International Conference on Bioinformatics, Biotechnology, and Biomedical Engineering (BIOMIC 2025)
Series: Advances in Health Sciences Research
Publication Date: 4 September 2026
ISBN: 978-94-6239-762-0
ISSN: 2468-5739
DOI: 10.2991/978-94-6239-762-0_31 How to use a DOI?
Open Access: Open Access This chapter is licensed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License (http://creativecommons.org/licenses/by-nc-nd/4.0/), which permits any noncommercial use, sharing, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license and indicate if you modified the licensed material. You do not have permission under this license to share adapted material derived from this chapter or parts of it.

Cite this article

ris enw bib

TY  - CONF
AU  - Fitriana Nur Hanifah
AU  - Indah Zunita Sari
AU  - Salsabilla Kristinawati
AU  - Alma Nur Azizah
AU  - Jeesica Hermayanti Pratama
AU  - Ratna Asmah Susidarti
AU  - Umah Rani Kuppusamy
PY  - 2026
DA  - 2026/09/04
TI  - The Potency of Chalcone Derivatives as Anticancer Agents: A Five-Decade Bibliometric Overview
BT  - Proceedings of the 6th International Conference on Bioinformatics, Biotechnology, and Biomedical Engineering (BIOMIC 2025)
PB  - Atlantis Press
SP  - 490
EP  - 515
SN  - 2468-5739
UR  - https://doi.org/10.2991/978-94-6239-762-0_31
DO  - 10.2991/978-94-6239-762-0_31
ID  - Hanifah2026
ER  -

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