Adverse Event-Based Drug Repurposing for Psoriasis: a Bioinformatics and in Silico Approach

DOI

10.2991/978-94-6239-762-0_30How to use a DOI?

Keywords

Repositioning; FAERS; GEO Dataset; Molecular Docking; Network Phar-Macology

Abstract

Psoriasis is a chronic autoimmune disease affecting approximately 3% of the global population, with no effective long-term treatment options. This study uses the FAERS database, network pharmacology, and molecular docking to investigate drug repurposing for psoriasis. The FAERS analysis identified ranitidine as a promising candidate, as it showed a negative association with psoriasis in the database. Network pharmacology revealed 13 overlapping genes between psoriasis and ranitidine, which were primarily involved in immune regulation and inflammation. Protein-protein interaction analysis highlighted IL1B as a central gene in the network. Molecular docking simulations further demonstrated that ranitidine interacts with several psoriasis-related proteins, including IL1B, PPARD, and PTPRC, although the binding affinities were generally weaker than those of native ligands. These findings suggest that ranitidine may influence psoriasis-related molecular pathways and support its potential for further experimental validation.

Copyright

© 2026 The Author(s)

Open Access

Open Access This chapter is licensed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License (http://creativecommons.org/licenses/by-nc-nd/4.0/), which permits any noncommercial use, sharing, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license and indicate if you modified the licensed material. You do not have permission under this license to share adapted material derived from this chapter or parts of it.

Download article (PDF)

TY  - CONF
AU  - Riznah al-Rizqiyyah
AU  - Corina Bilkisti
AU  - Putu Gita Iswari
AU  - Soni Siswanto
PY  - 2026
DA  - 2026/09/04
TI  - Adverse Event-Based Drug Repurposing for Psoriasis: a Bioinformatics and in Silico Approach
BT  - Proceedings of the 6th International Conference on Bioinformatics, Biotechnology, and Biomedical Engineering (BIOMIC 2025)
PB  - Atlantis Press
SP  - 474
EP  - 489
SN  - 2468-5739
UR  - https://doi.org/10.2991/978-94-6239-762-0_30
DO  - 10.2991/978-94-6239-762-0_30
ID  - al-Rizqiyyah2026
ER  -