Research Progress on Traditional Chinese Medicine Based on the PI3K/Akt/mTOR Pathway in Cardiovascular Disease Intervention

DOI

10.2991/978-94-6463-829-5_13How to use a DOI?

Keywords

PI3K/Akt/mTOR signaling pathway; cardiovascular diseases; traditional Chinese medicine treatment

Abstract

The phosphatidylinositol-3-kinase/protein kinase B/mammalian target of rapamycin (PI3K/Akt/mTOR) signaling pathway, an important axis in the cellular life cycle that controls growth, proliferation, apoptosis, and even the stability of the body’s material metabolism, plays an irreplaceable role in maintaining the balance of the intracellular environment. Initially, research on the PI3K/Akt/mTOR signaling pathway focused on the field of tumor biology. However, in recent years, research has revealed that this pathway is distributed throughout the whole organism and participates in the occurrence and development of many human diseases. We are well aware that the dysfunction of this pathway is closely related to many diseases, including neurodegenerative disorders, malignant tumors, and cardiovascular diseases, the world’s number one health killer. In the face of the serious threat of cardiovascular disease, traditional Chinese medicine (TCM) has long been proven to have unique therapeutic properties, which have been demonstrated in numerous experimental studies and clinical treatments. Based on this observation, we would like to explore the specific molecular mechanism of TCM in regulating the PI3K/Akt/mTOR pathway, and focus on its potential and value in the clinical application of cardiovascular diseases in the hope that this review will provide useful reference for the modernization of TCM.

Copyright

© 2025 The Author(s)

Open Access

Open Access This chapter is licensed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License (http://creativecommons.org/licenses/by-nc/4.0/), which permits any noncommercial use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license and indicate if changes were made.

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TY  - CONF
AU  - Huaqing Xi
AU  - Kai Liu
PY  - 2025
DA  - 2025/08/28
TI  - Research Progress on Traditional Chinese Medicine Based on the PI3K/Akt/mTOR Pathway in Cardiovascular Disease Intervention
BT  - Proceedings of the 2025 International Conference on Chemical Engineering and Biological Science (CEBS 2025)
PB  - Atlantis Press
SP  - 116
EP  - 121
SN  - 2352-5401
UR  - https://doi.org/10.2991/978-94-6463-829-5_13
DO  - 10.2991/978-94-6463-829-5_13
ID  - Xi2025
ER  -