Proceedings of the 2025 International Conference on Chemical Engineering and Biological Science (CEBS 2025)

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Preparation and Antibacterial Activity of Self-Assembled Nanoenzyme Based on Metal-Baicalin

Authors
Yun-Fei Gao1, Ya-Mu Xia1, *
1State Key Laboratory Base of Eco-chemical Engineering, College of Chemical Engineering, Qingdao University of Science and Technology, Qingdao, 266042, China
*Corresponding author. Email: xiayamu@126.com
Corresponding Author
Ya-Mu Xia
Available Online 28 August 2025.
DOI
10.2991/978-94-6463-829-5_12How to use a DOI?
Keywords
Baicalin; Nanozyme; Antibiosis
Abstract

This study constructed a metal coordination self-assembled Mn@BA nanoenzyme and studied its role in antibacterial. The appearance of Mn@BA is manifested as a nanoflower-like structure, and the diameter distribution is mainly concentrated around 920 nm. In the presence of H2O2, Mn@BA exhibits excellent peroxidase-like (POD) activity, which catalyzes the conversion of H2O2 into a hydroxyl radical (•OH). Mn@BA also has good photothermal conversion efficiency and excellent photothermal stability. It produces 1O2 under near-infrared irradiation, and jointly kills bacteria with •OH. The high temperature generated is not only conducive to killing bacteria, but also effectively improves •OH generation efficiency. The minimum inhibitory concentration (MIC) of Mn@BA+H2O2 is 20 μg mL-1, and the bactericidal rate of MRSA and AmprE. coli can reach 99.75% and 99.29%, with excellent antibacterial properties. Finally, in order to verify the safety of the material, cytotoxicity experiments and cytocompatibility experiments were performed. The experimental results showed that Mn@BA had low cytotoxicity and good biocompatibility.

Copyright
© 2025 The Author(s)
Open Access
Open Access This chapter is licensed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License (http://creativecommons.org/licenses/by-nc/4.0/), which permits any noncommercial use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license and indicate if changes were made.

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Volume Title
Proceedings of the 2025 International Conference on Chemical Engineering and Biological Science (CEBS 2025)
Series
Advances in Engineering Research
Publication Date
28 August 2025
ISBN
978-94-6463-829-5
ISSN
2352-5401
DOI
10.2991/978-94-6463-829-5_12How to use a DOI?
Copyright
© 2025 The Author(s)
Open Access
Open Access This chapter is licensed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License (http://creativecommons.org/licenses/by-nc/4.0/), which permits any noncommercial use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license and indicate if changes were made.

Cite this article

risenwbib
TY  - CONF
AU  - Yun-Fei Gao
AU  - Ya-Mu Xia
PY  - 2025
DA  - 2025/08/28
TI  - Preparation and Antibacterial Activity of Self-Assembled Nanoenzyme Based on Metal-Baicalin
BT  - Proceedings of the 2025 International Conference on Chemical Engineering and Biological Science (CEBS 2025)
PB  - Atlantis Press
SP  - 105
EP  - 115
SN  - 2352-5401
UR  - https://doi.org/10.2991/978-94-6463-829-5_12
DO  - 10.2991/978-94-6463-829-5_12
ID  - Gao2025
ER  -