Biologically Active Usaturated α,β-Ketones Containing a Cycloacetal Fragment

DOI

10.2991/978-94-6239-668-5_12How to use a DOI?

Keywords

Selective reduction; 1,3-dioxane; Aldol condensation; α,β-unsaturated ketones; Molecular docking

Abstract

Previously, we synthesized saturated ketones and unsaturated alcohols containing a 1,3-dioxane fragment via chemoselective reduction of unsaturated α,β-unsaturated ketones. Molecular docking of the obtained compounds was performed, and primary screening of the synthesized compounds was conducted using DIP-SLIDE rapid tests. The studies demonstrated that the selectively reduced derivatives exhibited lower bactericidal activity compared to the initial unsaturated α,β-unsaturated ketones.

Copyright

© 2026 The Author(s)

Open Access

Open Access This chapter is licensed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License (http://creativecommons.org/licenses/by-nc/4.0/), which permits any noncommercial use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license and indicate if changes were made.

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TY  - CONF
AU  - Elizaveta Akimova
AU  - Yana Bereznyak
AU  - Alexander Poptsov
AU  - Yulianna Borisova
AU  - Simon Zlotsky
AU  - Rimma Sultanova
PY  - 2026
DA  - 2026/05/14
TI  - Biologically Active Usaturated α,β-Ketones Containing a Cycloacetal Fragment
BT  - Proceedings of the International Conference on Current Problems in Engineering and Applied Sciences (ICCPEAS 2025)
PB  - Atlantis Press
SP  - 112
EP  - 119
SN  - 2352-5401
UR  - https://doi.org/10.2991/978-94-6239-668-5_12
DO  - 10.2991/978-94-6239-668-5_12
ID  - Akimova2026
ER  -