The Role of Curcuma Zedoaria Extract on PlDF in Diabetic Nephropathy Wistar Rats

Meisya Melissa; Linda Chiuman; Fiska Maya Wardhani; Dewi Purwanti; Trishna Trishna

doi:10.2991/978-94-6463-664-2_17

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The Role of Curcuma Zedoaria Extract on PlDF in Diabetic Nephropathy Wistar Rats

Authors

Meisya Melissa¹, Linda Chiuman¹^{, *}, Fiska Maya Wardhani¹, Dewi Purwanti¹, Trishna Trishna¹

¹Universitas Prima Indonesia, Department of Medical, Medan, Indonesia

^*Corresponding author. Email: lindachiuman@unprimdn.ac.id

Corresponding Author

Linda Chiuman

Available Online 31 March 2025.

DOI: 10.2991/978-94-6463-664-2_17 How to use a DOI?
Keywords: Curcuma Zedoaria; Diabetic Nephropathy; PlGF; Blood Glucose; Kidney Histopathology
Abstract: This study evaluated the effects of Curcuma zedoaria extract on blood glucose, Placental Growth Factor (PlGF), and kidney histopathology in diabetic nephropathy (DN) Wistar rats. DN, a severe diabetic complication, leads to progressive kidney damage. Using a post-test-only control group design, diabetes was induced in male Wistar rats with alloxan, and Curcuma zedoaria extract was administered orally at doses of 250 mg, 500 mg, and 750 mg for two weeks. Blood glucose, PlGF, and kidney histopathology were assessed. Data were analyzed using ANOVA, Kruskal-Wallis, and Bonferroni tests. Results showed significant blood glucose reduction (p < 0.01), with the 750 mg dose being most effective. However, no significant differences were observed in PlGF levels (p = 0.902) or kidney histopathology (p = 0.152). These findings suggest that high-dose Curcuma zedoaria effectively reduces blood glucose in DN, but its effects on PlGF and kidney histopathology are limited.
Copyright: © 2025 The Author(s)
Open Access: Open Access This chapter is licensed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License (http://creativecommons.org/licenses/by-nc/4.0/), which permits any noncommercial use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license and indicate if changes were made.

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Volume Title: Proceedings of the 1st International Conference on Lifestyle Diseases and Natural Medicine (ICOLIFEMED 2024)
Series: Advances in Health Sciences Research
Publication Date: 31 March 2025
ISBN: 978-94-6463-664-2
ISSN: 2468-5739
DOI: 10.2991/978-94-6463-664-2_17 How to use a DOI?
Open Access: Open Access This chapter is licensed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License (http://creativecommons.org/licenses/by-nc/4.0/), which permits any noncommercial use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license and indicate if changes were made.

Cite this article

ris enw bib

TY  - CONF
AU  - Meisya Melissa
AU  - Linda Chiuman
AU  - Fiska Maya Wardhani
AU  - Dewi Purwanti
AU  - Trishna Trishna
PY  - 2025
DA  - 2025/03/31
TI  - The Role of Curcuma Zedoaria Extract on PlDF in Diabetic Nephropathy Wistar Rats
BT  - Proceedings of the 1st International Conference on Lifestyle Diseases and Natural Medicine (ICOLIFEMED 2024)
PB  - Atlantis Press
SP  - 167
EP  - 176
SN  - 2468-5739
UR  - https://doi.org/10.2991/978-94-6463-664-2_17
DO  - 10.2991/978-94-6463-664-2_17
ID  - Melissa2025
ER  -

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