Anticancer Effects of Vitex trifolia Extract on Cervical Cancer Animal Models: A Study of Genetic Mutations and Anti-Apoptotic Bcl-2 Gene Expression
- DOI
- 10.2991/978-94-6463-664-2_19How to use a DOI?
- Keywords
- Vitex trifolia; Cervical Cancer; Genetic Mutations; Anti-Apoptotic Bcl-2; Resistance
- Abstract
This study investigates the potential of Vitex trifolia (legundi) extract to reduce resistance to radiation and chemotherapy in epithelial cancer by targeting the Bcl-2 apoptosis pathway. The objectives include (1) characterizing Casticin and Labdane-Type Diterpene compounds; (2) analyzing Bcl-2 gene mutations in chemotherapy resistance; (3) studying molecular docking interactions with Bcl-2 protein; (4) evaluating histopathological effects in cervical cancer animal models; (5) assessing apoptosis via Bcl-2 expression changes; and (6) ensuring safety through liver and kidney function tests. Using in vitro and in vivo methods, the study employed phytochemical screening, molecular docking, and a rat cervical cancer model treated with Vitex trifolia extract. GC-MS confirmed the presence of Casticin and Labdane-Type Diterpene. Molecular docking revealed strong interactions between Labdane-Type Diterpene and Bcl-2. Histopathological improvements and reduced Bcl-2 expression were observed, suggesting Vitex trifolia extract could enhance cancer treatment efficacy by overcoming chemotherapy resistance.
- Copyright
- © 2025 The Author(s)
- Open Access
- Open Access This chapter is licensed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License (http://creativecommons.org/licenses/by-nc/4.0/), which permits any noncommercial use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license and indicate if changes were made.
Cite this article
TY - CONF AU - Humairah Medina Liza Lubis AU - Emni Purwoningsih AU - Anggi Yulisna Frisilia Saputri PY - 2025 DA - 2025/03/31 TI - Anticancer Effects of Vitex trifolia Extract on Cervical Cancer Animal Models: A Study of Genetic Mutations and Anti-Apoptotic Bcl-2 Gene Expression BT - Proceedings of the 1st International Conference on Lifestyle Diseases and Natural Medicine (ICOLIFEMED 2024) PB - Atlantis Press SP - 194 EP - 218 SN - 2468-5739 UR - https://doi.org/10.2991/978-94-6463-664-2_19 DO - 10.2991/978-94-6463-664-2_19 ID - Lubis2025 ER -