Anticancer Effects of Vitex trifolia Extract on Cervical Cancer Animal Models: A Study of Genetic Mutations and Anti-Apoptotic Bcl-2 Gene Expression

DOI

10.2991/978-94-6463-664-2_19How to use a DOI?

Keywords

Vitex trifolia; Cervical Cancer; Genetic Mutations; Anti-Apoptotic Bcl-2; Resistance

Abstract

This study investigates the potential of Vitex trifolia (legundi) extract to reduce resistance to radiation and chemotherapy in epithelial cancer by targeting the Bcl-2 apoptosis pathway. The objectives include (1) characterizing Casticin and Labdane-Type Diterpene compounds; (2) analyzing Bcl-2 gene mutations in chemotherapy resistance; (3) studying molecular docking interactions with Bcl-2 protein; (4) evaluating histopathological effects in cervical cancer animal models; (5) assessing apoptosis via Bcl-2 expression changes; and (6) ensuring safety through liver and kidney function tests. Using in vitro and in vivo methods, the study employed phytochemical screening, molecular docking, and a rat cervical cancer model treated with Vitex trifolia extract. GC-MS confirmed the presence of Casticin and Labdane-Type Diterpene. Molecular docking revealed strong interactions between Labdane-Type Diterpene and Bcl-2. Histopathological improvements and reduced Bcl-2 expression were observed, suggesting Vitex trifolia extract could enhance cancer treatment efficacy by overcoming chemotherapy resistance.

Copyright

© 2025 The Author(s)

Open Access

Open Access This chapter is licensed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License (http://creativecommons.org/licenses/by-nc/4.0/), which permits any noncommercial use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license and indicate if changes were made.

Download article (PDF)

TY  - CONF
AU  - Humairah Medina Liza Lubis
AU  - Emni Purwoningsih
AU  - Anggi Yulisna Frisilia Saputri
PY  - 2025
DA  - 2025/03/31
TI  - Anticancer Effects of Vitex trifolia Extract on Cervical Cancer Animal Models: A Study of Genetic Mutations and Anti-Apoptotic Bcl-2 Gene Expression
BT  - Proceedings of the 1st International Conference on Lifestyle Diseases and Natural Medicine (ICOLIFEMED 2024)
PB  - Atlantis Press
SP  - 194
EP  - 218
SN  - 2468-5739
UR  - https://doi.org/10.2991/978-94-6463-664-2_19
DO  - 10.2991/978-94-6463-664-2_19
ID  - Lubis2025
ER  -