Paraboea Leuserensis as Therapeutic Agents for Wound Healing Application: A Review

DOI

10.2991/978-94-6463-962-9_28How to use a DOI?

Keywords

Paraboea Leuserensis; Wound Healing; VEGF; Angiogenesis; Topical

Abstract

Chronic wounds remain a major clinical and economic challenge worldwide. Natural-product–based topical therapies are attractive alternatives due to biocompatibility, multi-target activity and cost-effectiveness. Paraboea leuserensis, an Indonesian endemic medicinal plant, has recently attracted attention for its rich flavonoid- and phenolic-containing extracts and promising preclinical wound-healing activity. This narrative review synthesizes current phytochemical, mechanistic, in vitro and in vivo evidence on P. leuserensis as a wound-healing agent, with emphasis on VEGF-mediated angiogenesis, antioxidant and antimicrobial properties, and formulation strategies for clinical translation. We discuss comparative benefits relative to other phytotherapeutics, identify major translational obstacles (standardization, toxicology, regulatory pathways), and propose priority research directions including marker-based standardization, advanced topical delivery (hydrogel or nanoformulations), and early phase clinical testing. The review integrates the authors’ experimental data with contemporary literature to outline a practical roadmap for advancing P. leuserensis toward clinical application.

Copyright

© 2025 The Author(s)

Open Access

Open Access This chapter is licensed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License (http://creativecommons.org/licenses/by-nc/4.0/), which permits any noncommercial use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license and indicate if changes were made.

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TY  - CONF
AU  - Refi Ikhtiari
AU  - Dyah Wijiana Heryani
AU  - Fiska Maya Wardhani
PY  - 2026
DA  - 2026/01/02
TI  - Paraboea Leuserensis as Therapeutic Agents for Wound Healing Application: A Review
BT  - Proceedings of the 2nd International Conference on Lifestyle Diseases and Natural Medicine (ICOLIFEMED 2025)
PB  - Atlantis Press
SP  - 282
EP  - 288
SN  - 2468-5739
UR  - https://doi.org/10.2991/978-94-6463-962-9_28
DO  - 10.2991/978-94-6463-962-9_28
ID  - Ikhtiari2026
ER  -