Experimental Assessment of Zinc and Vitamin E Combination on Hemoglobin, Glycemic Control, and Neutrophil–Lymphocyte Ratio in Staphylococcus aureus Induced Septic Rats

DOI

10.2991/978-94-6463-962-9_2How to use a DOI?

Keywords

Staphylococcus aureus; Sepsis; Zinc; Vitamin E; Rat models

Abstract

Sepsis caused by Staphylococcus aureus disrupts hematologic, metabolic, and immune functions. Zinc and vitamin E, with antioxidant and immunomodulatory properties, may mitigate these effects. Thirty male Wistar rats aged 12 to 16 weeks and weighing 150 to 200 grams were randomized into six groups of five. Group 1 served as normal control, Group 2 as sepsis control, and Group 3 as positive control treated with levofloxacin 45 mg per kg per day combined with zinc 0.9 mg per kg per day and vitamin E 250 mg per kg per day. Groups 4, 5, and 6 received zinc at doses of 0.9, 1.8, and 2.7 mg per kg per day respectively, each combined with vitamin E 250 mg per kg per day. Sepsis was induced on Day 1 by intraperitoneal injection of S. aureus at standard colony forming units per mL. Treatments were administered from Days 3 to 8, and outcomes were evaluated on Day 9. Zinc plus vitamin E significantly restored hemoglobin, normalized neutrophil lymphocyte ratio, and reduced fasting glucose compared with the sepsis control. The intermediate zinc dose demonstrated the most consistent improvement, suggesting therapeutic potential against S. aureus-induced sepsis.

Copyright

© 2025 The Author(s)

Open Access

Open Access This chapter is licensed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License (http://creativecommons.org/licenses/by-nc/4.0/), which permits any noncommercial use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license and indicate if changes were made.

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TY  - CONF
AU  - Olivia Des Vinca Albahana Napitupulu
AU  - Gusbakti Rusip
AU  - Maya Sari Mutia
PY  - 2026
DA  - 2026/01/02
TI  - Experimental Assessment of Zinc and Vitamin E Combination on Hemoglobin, Glycemic Control, and Neutrophil–Lymphocyte Ratio in Staphylococcus aureus Induced Septic Rats
BT  - Proceedings of the 2nd International Conference on Lifestyle Diseases and Natural Medicine (ICOLIFEMED 2025)
PB  - Atlantis Press
SP  - 5
EP  - 15
SN  - 2468-5739
UR  - https://doi.org/10.2991/978-94-6463-962-9_2
DO  - 10.2991/978-94-6463-962-9_2
ID  - Napitupulu2026
ER  -