Proceedings of the International Conference on Resilient Innovations for Subsistence Environment (IC-RISE-2025)

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Development and Characterization of Mouth Dissolving Tablets of Dolutegravir Sodium

Authors
Battula Sowjanya Lakshmi1, *, Anne Ramu2, Suryadevara Vidyadhara3
1Assistant Professor, Department of Pharmaceutics, Chebrolu Hanumaiah Institute of Pharmaceutical Sciences, Chandramoulipuram, Chowdavaram, Guntur, Andhra Pradesh, India, 522019
2Professor, Department of Pharmaceutics, Chebrolu Hanumaiah Institute of Pharmaceutical Sciences, Chandramoulipuram, Chowdavaram, Guntur, Andhra Pradesh, India, 522019
3Professor & Principal, Department of Pharmaceutics, Chebrolu Hanumaiah Institute of Pharmaceutical Sciences, Chandramoulipuram, Chowdavaram, Guntur, Andhra Pradesh, India, 522019
*Corresponding author. Email: sowjipharma6@gmail.com
Corresponding Author
Battula Sowjanya Lakshmi
Available Online 5 March 2026.
DOI
10.2991/978-94-6239-606-7_18How to use a DOI?
Keywords
Dolutegravir; Pregelatinized Starch; solid dispersion; Mouth-Dissolving tablets
Abstract

This study primarily used solid dispersion technology to address the problem of Dolutegravir’s poor solubility and rate of dissolution. Using pregelatinized starch as the carrier, solid dispersions were made by physical mixing, kneading, and solvent evaporation techniques. The performance of the resulting formulations was compared. Solvent evaporation technique yielded optimal solid dispersions, demonstrating the highest dissolution rates. These optimized dispersions were then processed into Mouth-Dissolving tablets using direct compression. The resulting tablets (specifically formulation DFT3) met all pharmacopeial standards for stability and physical characteristics, and exhibited excellent drug release, achieving approximately 99% release within 60 minutes, following first-order kinetics. This formulation represents a significant advance toward improving the bioavailability of Dolutegravir.

Copyright
© 2026 The Author(s)
Open Access
Open Access This chapter is licensed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License (http://creativecommons.org/licenses/by-nc/4.0/), which permits any noncommercial use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license and indicate if changes were made.

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Volume Title
Proceedings of the International Conference on Resilient Innovations for Subsistence Environment (IC-RISE-2025)
Series
Advances in Biological Sciences Research
Publication Date
5 March 2026
ISBN
978-94-6239-606-7
ISSN
2468-5747
DOI
10.2991/978-94-6239-606-7_18How to use a DOI?
Copyright
© 2026 The Author(s)
Open Access
Open Access This chapter is licensed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License (http://creativecommons.org/licenses/by-nc/4.0/), which permits any noncommercial use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license and indicate if changes were made.

Cite this article

risenwbib
TY  - CONF
AU  - Battula Sowjanya Lakshmi
AU  - Anne Ramu
AU  - Suryadevara Vidyadhara
PY  - 2026
DA  - 2026/03/05
TI  - Development and Characterization of Mouth Dissolving Tablets of Dolutegravir Sodium
BT  - Proceedings of the International Conference on Resilient Innovations for Subsistence Environment (IC-RISE-2025)
PB  - Atlantis Press
SP  - 170
EP  - 184
SN  - 2468-5747
UR  - https://doi.org/10.2991/978-94-6239-606-7_18
DO  - 10.2991/978-94-6239-606-7_18
ID  - Lakshmi2026
ER  -