The Effect of Polysaccharide Peptide (PsP) on the Improvement of Low-Density Lipoprotein (LDL) Profile Levels in Active Smokers with Dyslipidemia

DOI

10.2991/978-94-6239-770-5_4How to use a DOI?

Keywords

Active Smokers; Dyslipidemia; Ganoderma lucidum; Low-density lipoprotein (LDL); Polysaccharide peptides

Abstract

Indonesia continues to have a substantial smoking burden, and tobacco exposure can worsen dyslipidemia through oxidative stress and inflammation. Polysaccharide peptide (PsP) from Ganoderma lucidum contains β-D-glucan and other bioactive constituents that may support lipid control. This study assessed the LDL-C response to PsP in active smokers with dyslipidemia. Twenty-eight male students aged 18-21 years participated in a pretest-posttest controlled experiment. The intervention group (n=14) received 500 mg PsP orally each day for 30 days; the control group (n=14) received no PsP. LDL-C was determined before and after the study period. Paired t-tests assessed change within groups, and independent t-tests compared the magnitude of change. LDL-C fell significantly after PsP administration (p<0.001), but remained unchanged in controls (p=0.875). The difference in change between groups was significant (p<0.001). PsP may act through β-D-glucan-related antioxidant, anti-inflammatory, and lipid-regulating pathways. Thus, 30-day supplementation with 500 mg/day PsP was associated with lower LDL-C in young active smokers with dyslipidemia. Confirmation in larger, longer, and placebo-controlled studies is needed.

Copyright

© 2026 The Author(s)

Open Access

Open Access This chapter is licensed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License (http://creativecommons.org/licenses/by-nc/4.0/), which permits any noncommercial use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license and indicate if changes were made.

Download article (PDF)

TY  - CONF
AU  - Titin Andri Wihastuti
AU  - Zahra Nazkiano
AU  - Faza Zahruna Fakhra
AU  - Wiesye Roryn Sanyoto
AU  - Kumboyono Kumboyono
AU  - Indah Nur Chomsy
PY  - 2026
DA  - 2026/09/04
TI  - The Effect of Polysaccharide Peptide (PsP) on the Improvement of Low-Density Lipoprotein (LDL) Profile Levels in Active Smokers with Dyslipidemia
BT  - Proceedings of the 6th International Nursing and Health Sciences Symposium (INHSS 2025)
PB  - Atlantis Press
SP  - 23
EP  - 32
SN  - 2468-5739
UR  - https://doi.org/10.2991/978-94-6239-770-5_4
DO  - 10.2991/978-94-6239-770-5_4
ID  - Wihastuti2026
ER  -