The Impact of Glycated Hemoglobin (HbA1c) Levels on the Duration of Diabetic Ketoacidosis Recovery in Patients of Different Age Groups

DOI

10.2991/978-94-6463-984-1_3How to use a DOI?

Keywords

Diabetic ketoacidosis; Glycated Hemoglobin; Recovery

Abstract

Diabetic ketoacidosis (DKA) remains one of the leading causes of hospitalization, mortality, and severe complications, especially in childhood and adolescence. Understanding the interplay between HbA1c levels and DKA resolution time is of paramount importance, as it can provide insights into the underlying pathophysiology, guide treatment strategies, and ultimately improve patient outcomes. Current retrospective study was conducted between January 2019 and December 2023 and analyzes 798 cases of diabetic ketoacidosis (DKA) in patients with type 1 diabetes mellitus. The results of the study indicated a statistically significant positive correlation between HbA1c levels and the duration of DKA resolution across all age groups (r= 0.312, p<0.0001). There were no significant differences between any of the age groups in duration of DKA. The main factors determining the speed of recovery from DKA are the volume of infusion therapy, timely insulin administration, and correction of electrolyte imbalances. The average daily dose of insulin in the ICU increases with age. The duration of DKA remains stable across age groups, despite significant differences in insulin requirements. The adolescent group (13–18 years) demonstrates the highest HbA1c levels and a greater need for insulin, which requires additional monitoring and educational programs aimed at improving adherence to therapy. Patients with high HbA1c require an individualized approach to insulin therapy, especially during DKA, with possible dose adjustments depending on the level of insulin resistance. Regular monitoring of HbA1c, strengthening educational activities in the adolescent group, and a special approach to frequently hospitalized patients are the key factors in successful management of patients with type 1 diabetes and prevention of DKA.

Copyright

© 2025 The Author(s)

Open Access

Open Access This chapter is licensed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License (http://creativecommons.org/licenses/by-nc/4.0/), which permits any noncommercial use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license and indicate if changes were made.

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TY  - CONF
AU  - Anna V. Alieva
AU  - Azamat A. Kojanazarov
AU  - Zebo A. Salixova
AU  - Nazokat E. Ismoilova
AU  - Bakhora U. Nazarova
PY  - 2025
DA  - 2025/12/26
TI  - The Impact of Glycated Hemoglobin (HbA1c) Levels on the Duration of Diabetic Ketoacidosis Recovery in Patients of Different Age Groups
BT  - Proceedings of the Turakulov Readings 2025 Conference (TR 2025)
PB  - Atlantis Press
SP  - 21
EP  - 30
SN  - 2468-5739
UR  - https://doi.org/10.2991/978-94-6463-984-1_3
DO  - 10.2991/978-94-6463-984-1_3
ID  - Alieva2025
ER  -