Mechanisms and Clinical Applications of Immunotherapy in Cancer Treatment

DOI

10.2991/978-94-6463-829-5_29How to use a DOI?

Keywords

Cancer Treatment; Immunotherapy; Clinical Applications

Abstract

Cancer immunotherapy has become a revolutionary approach following surgery, chemotherapy and targeted therapy by activating or enhancing the body’s immune system against cancers. Its core mechanisms include CAR-T therapy, which modifies T cells, and checkpoint blockade therapy, which relieves immunosuppression. CAR-T endows T cells with the ability to specifically recognize cancer antigens through genetic engineering, achieving a response rate of up to 89% in blood cancers; checkpoint inhibitors (such as anti-CTLA-4, PD-1/PD-L1 antibodies) restore anti-cancer activity by blocking T cell inhibitory signals, significantly prolonging the survival of patients with melanoma and other solid cancers. Clinical applications have shown that CAR-T therapy has led to complete remission in many cases, while checkpoint inhibitors achieve long-term remission in patients with metastatic cancers. Current research focuses on multi-target synergistic interventions, modulatable CAR-T designs, and combination therapy strategies to overcome individual response differences and solid cancer microenvironment barriers. Despite challenges such as toxicity management and resistance mechanisms, immunotherapy has reshaped the cancer treatment landscape. The surge in capital investment marks the official entry of cancer treatment into the era of precision immunotherapy.

Copyright

© 2025 The Author(s)

Open Access

Open Access This chapter is licensed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License (http://creativecommons.org/licenses/by-nc/4.0/), which permits any noncommercial use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license and indicate if changes were made.

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TY  - CONF
AU  - Linshuo Wang
PY  - 2025
DA  - 2025/08/28
TI  - Mechanisms and Clinical Applications of Immunotherapy in Cancer Treatment
BT  - Proceedings of the 2025 International Conference on Chemical Engineering and Biological Science (CEBS 2025)
PB  - Atlantis Press
SP  - 295
EP  - 302
SN  - 2352-5401
UR  - https://doi.org/10.2991/978-94-6463-829-5_29
DO  - 10.2991/978-94-6463-829-5_29
ID  - Wang2025
ER  -