Proceedings of the 2025 International Conference on Chemical Engineering and Biological Science (CEBS 2025)

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Applications of Stem Cell Therapy to Geographic Atrophy

Authors
Shihan Sun1, *
1Emergency and Trauma College, Hainan Medical University, Haikou, 570100, China
*Corresponding author. Email: bolangfu@qq.com
Corresponding Author
Shihan Sun
Available Online 28 August 2025.
DOI
10.2991/978-94-6463-829-5_28How to use a DOI?
Keywords
geographic atrophy (GA); stem cell therapy; retinal pigment epithelial cells; age-related macular degeneration
Abstract

As a late non-neovascular manifestation of age-related macular degeneration, geographic atrophy (GA) is characteristic of irreversible atrophy of retinal pigment epithelium and photoreceptor. It is one of major pathogenesis of global blinding. Current therapies (e.g. complement inhibitor) can only slow down progress of focus and they fail to realize functional cure. Recently, stem cell therapy provides a new direction for treatment of GA, including applications of induced pluripotent stem cells (iPSCs), embryonic stem cells (ESCs) and mesenchymal stem cells (MSCs). Although some clinical tests have achieved progresses, the stem cell integration efficiency, immunological rejection and long-term functional maintenance are still critical challenges. In future, the effect of stem cell therapy has to be optimized by combining gene editing, biomaterials and multi-modal strategies. In this study, the scientific bottlenecks and transfer potentials of stem cell therapy for GA were discussed by reviewing its mechanism, clinical progresses and prospects.

Copyright
© 2025 The Author(s)
Open Access
Open Access This chapter is licensed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License (http://creativecommons.org/licenses/by-nc/4.0/), which permits any noncommercial use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license and indicate if changes were made.

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Volume Title
Proceedings of the 2025 International Conference on Chemical Engineering and Biological Science (CEBS 2025)
Series
Advances in Engineering Research
Publication Date
28 August 2025
ISBN
978-94-6463-829-5
ISSN
2352-5401
DOI
10.2991/978-94-6463-829-5_28How to use a DOI?
Copyright
© 2025 The Author(s)
Open Access
Open Access This chapter is licensed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License (http://creativecommons.org/licenses/by-nc/4.0/), which permits any noncommercial use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license and indicate if changes were made.

Cite this article

risenwbib
TY  - CONF
AU  - Shihan Sun
PY  - 2025
DA  - 2025/08/28
TI  - Applications of Stem Cell Therapy to Geographic Atrophy
BT  - Proceedings of the 2025 International Conference on Chemical Engineering and Biological Science (CEBS 2025)
PB  - Atlantis Press
SP  - 287
EP  - 294
SN  - 2352-5401
UR  - https://doi.org/10.2991/978-94-6463-829-5_28
DO  - 10.2991/978-94-6463-829-5_28
ID  - Sun2025
ER  -