Proceedings of the 2nd International Conference on Lifestyle Diseases and Natural Medicine (ICOLIFEMED 2025)

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Vitamin D Receptor Polymorphisms in Systemic Autoimmune Rheumatic Diseases: Insights from Asian and European Populations

Authors
Herlina Yani1, *, Linda Chiuman2, Chrismis Novalinda Ginting2
1Departement of Internal Medicine, The Faculty of Medicine, Dentistry, and Health Sciences, Universitas Prima Indonesia, Medan, Indonesia
2The Faculty of Medicine, Dentistry, and Health Sciences, Universitas Prima Indonesia, Medan, Indonesia
*Corresponding author. Email: yani_herlina@yahoo.co.id
Corresponding Author
Herlina Yani
Available Online 2 January 2026.
DOI
10.2991/978-94-6463-962-9_26How to use a DOI?
Keywords
lupus erythematosus; rheumatoid arthritis; systemic autoimmune rheumatic diseases; VDR polymorphism; vitamin D receptor
Abstract

Background: Vitamin D and its receptor (VDR) play a pivotal role in immune regulation, with polymorphisms in the VDR gene implicated in susceptibility to systemic autoimmune rheumatic diseases (SARDs). Objective: This review compares findings from Asian and European populations regarding VDR polymorphisms and their association with SARDs, highlighting implications for future research in Indonesia. Methods: Literature was systematically searched in PubMed, Scopus, and Web of Science for studies and meta-analyses published between 2010–2023. Results: Asian studies generally demonstrate stronger associations between VDR polymorphisms (especially FokI and BsmI) and SARD risk, while European studies often report weaker or inconsistent associations. Conclusion: This is the first review to directly compare Asian and European data on VDR polymorphisms in SARDs. The results highlight the population-dependent nature of these associations and emphasize the need for region-specific studies, particularly in Indonesia

Copyright
© 2025 The Author(s)
Open Access
Open Access This chapter is licensed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License (http://creativecommons.org/licenses/by-nc/4.0/), which permits any noncommercial use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license and indicate if changes were made.

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Volume Title
Proceedings of the 2nd International Conference on Lifestyle Diseases and Natural Medicine (ICOLIFEMED 2025)
Series
Advances in Health Sciences Research
Publication Date
2 January 2026
ISBN
978-94-6463-962-9
ISSN
2468-5739
DOI
10.2991/978-94-6463-962-9_26How to use a DOI?
Copyright
© 2025 The Author(s)
Open Access
Open Access This chapter is licensed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License (http://creativecommons.org/licenses/by-nc/4.0/), which permits any noncommercial use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license and indicate if changes were made.

Cite this article

risenwbib
TY  - CONF
AU  - Herlina Yani
AU  - Linda Chiuman
AU  - Chrismis Novalinda Ginting
PY  - 2026
DA  - 2026/01/02
TI  - Vitamin D Receptor Polymorphisms in Systemic Autoimmune Rheumatic Diseases: Insights from Asian and European Populations
BT  - Proceedings of the 2nd International Conference on Lifestyle Diseases and Natural Medicine (ICOLIFEMED 2025)
PB  - Atlantis Press
SP  - 259
EP  - 266
SN  - 2468-5739
UR  - https://doi.org/10.2991/978-94-6463-962-9_26
DO  - 10.2991/978-94-6463-962-9_26
ID  - Yani2026
ER  -