Therapeutic Potential of Moringa oleifera Leaf Cream in Promoting Wound Healing Through VEGF and Collagen Modulation in Burn Injury

DOI

10.2991/978-94-6463-962-9_25How to use a DOI?

Keywords

Moringa oleifera; burn wound; VEGF expression; collagen; topical cream; immunohistochemistry; Masson’s Trichrome

Abstract

Burn injuries are severe tissue traumas that induce complex inflammatory responses and require effective treatments to support the healing process. Vascular Endothelial Growth Factor (VEGF) and collagen play crucial roles in angiogenesis and tissue remodeling during wound healing. Moringa oleifera L. is known to contain bioactive compounds such as flavonoids and vitamin C with anti-inflammatory and regenerative properties. This study aimed to evaluate the potential of M. oleifera leaf extract cream in enhancing VEGF protein expression and collagen density in second-degree burn wounds in mice (Mus musculus). An experimental study was conducted using topical M. oleifera cream at concentrations of 1.25%, 2.5%, and 5% applied to thermally induced second-degree burns. VEGF expression was analyzed using immunohistochemistry, while collagen density was assessed with Masson’s Trichrome staining. The results showed a significant increase in VEGF expression and collagen density in treatment groups compared to negative controls. The 5% concentration yielded the most pronounced effect, indicating strong wound healing activity through enhanced angiogenesis and tissue remodeling. Moringa oleifera leaf extract cream shows promising potential as an effective topical agent for second-degree burn wound healing, especially by increasing VEGF expression and collagen density, with 5% being the optimal concentration.

Copyright

© 2025 The Author(s)

Open Access

Open Access This chapter is licensed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License (http://creativecommons.org/licenses/by-nc/4.0/), which permits any noncommercial use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license and indicate if changes were made.

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TY  - CONF
AU  - Envhi Wina Amalia
AU  - Linda Chiuman
AU  - Edy Fachrial
PY  - 2026
DA  - 2026/01/02
TI  - Therapeutic Potential of Moringa oleifera Leaf Cream in Promoting Wound Healing Through VEGF and Collagen Modulation in Burn Injury
BT  - Proceedings of the 2nd International Conference on Lifestyle Diseases and Natural Medicine (ICOLIFEMED 2025)
PB  - Atlantis Press
SP  - 247
EP  - 258
SN  - 2468-5739
UR  - https://doi.org/10.2991/978-94-6463-962-9_25
DO  - 10.2991/978-94-6463-962-9_25
ID  - Amalia2026
ER  -